ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

The Significance of Selenium

Print Page
Email Article

Oral Chromium Picolinate Improves Insulin Resistance in Rat Model

  [ 28 votes ]   [ Discuss This Article ] • June 4, 2002

BURLINGTON, Vt.-- Obese rats that were administered oral chromium picolinate for three months exhibited improved insulin sensitivity and glucose disappearance as compared to control rats, according to researchers from the University of Vermont College of Medicine and Canadian colleagues from the University of Alberta in Edmonton who published their study in the June issue of the Journal of Nutrition (132, 6:1107-14, 2002) (

Because previous research suggested that chromium picolinate decreases insulin levels and improves glucose disposal in obese and diabetic populations, investigators sought to determine whether oral chromium picolinate supplementation would aid in the treatment of insulin resistance syndrome.

Male lean and obese hyperinsulinemic rats (rats with insulin resistance syndrome) were randomly assigned to either a control group or to a treatment group, receiving oral chromium picolinate (80 mcg/kg/d) in water. After three months, the obese rats in the treatment group had significantly lower fasting insulin levels and improved glucose disappearance compared with obese controls. In addition, the obese rats in the treatment group exhibited lower plasma total cholesterol and elevated high-density lipoprotein (HDL, "good") cholesterol levels compared to control.

Chromium picolinate supplementation was also seen to significantly enhance membrane-associated glucose transporter (Glut)-4 in obese rats after insulin stimulation, which relates to the body's ability to dispose of glucose properly. The Glut-4 transporter is required for moving glucose into cells where it can be burned. "These Glut-4 translocators have to go to the cell surface, and they basically make an opening in the surface of the cell to allow the glucose to go in to be metabolized," explained James Komorowski, director of technical affairs at Purchase, N.Y.-based Nutrition 21, the company that provided the active compound (as Chromax® chromium picolinate) for the study. While there was no difference in total skeletal muscle Glut-4 transporter among the groups, chromium picolinate supplementation was shown to enhance the activity of the Glut-4 transporter in the obese rats.

Researchers also noted that chromium picolinate supplementation did not alter plasma glucose or cholesterol levels in the lean rats. "That's a good thing in that if there's a healthy, normal animal, the administration doesn't lower blood sugar levels below normal," Komorowski said. "It was only effective in lowering elevated blood sugar levels in animals that had bad carbohydrate metabolism. But it didn't change levels in the normal animals, which you wouldn't want it to do."

Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor® Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
Guarding Against the Dangers of Vitamin D Deficiency Guarding Against the Dangers of Vitamin D Deficiency

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map