ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Omega Fix for Obesity: How the Right Fats Fight Fat

How Pomegranate May Protect Against Cancer

Potential of Quercetin in the Treatment of Melanoma

Trimming the spare tire: Canola oil may cut belly fat

Supplementation with vitamins C and E associated with decreased risk of cognitive impairment, dement...

 
Print Page
Email Article

Protein May Reduce Susceptibility to Autoimmune Disease

  [ 44 votes ]   [ Discuss This Article ]
www.ProHealth.com • May 18, 2004


A recent discovery provides new information about critical cellular signals that may be involved in autoimmune diseases like multiple sclerosis, rheumatoid arthritis, and type 1 diabetes. Scientists have identified a protein that appears to regulate the function of the immune cells, called T cells, which contribute to the pathogenesis associated with autoimmune disease. The research is published in the May issue of Immunity.

Cytotoxic T lymphocytes are immune cells that normally protect the body from infection by destroying cancer cells and cells infected with dangerous bacteria or viruses. However, overactivation of T cells can lead to an assault on the body's own healthy tissues, leading to some form of autoimmune disease. The protein cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is well known as an important regulator of the immune system and plays a critical role in down-regulating T cell responses.

Dr. Linda S. Wicker from the Cambridge Institute for Medical Research and Dr. Vijay K. Kuchroo from the Center for Neurologic Diseases at Brigham and Women's Hospital and Harvard Medical School examined the function of a newly discovered naturally occurring form of CTLA-4 called ligand independent CTLA-4 (liCTLA-4) because low levels of this alternate form of CTLA-4 have been associated with autoimmune disease susceptibility. The researchers found that liCTLA-4 is present in T cells and vigorously inhibits T cell responses. There was an enhanced expression of liCTLA-4 protein in the T cells of a special strain of mice that is resistant to type 1 diabetes compared to a strain of the mice that is susceptible to the disease.

The researchers conclude that increased expression of liCTLA-4 reduces activation of T cells and thus plays a role in preventing susceptibility to T cell-mediated autoimmune diseases. "The discovery of a new form of CTLA-4 was a completely unexpected result and demonstrates that the study of natural variation of genes altering autoimmune diseases such as type 1 diabetes can yield new insights even about molecules that have already been the subject of extensive study, such as CTLA-4," explains Dr. Wicker. According to Dr. Kuchroo, "This taught us that in many cases the disease may not be due to big changes in the affected genes but instead due to subtle differences in the amount of alternate forms of the gene that are expressed."

Lalitha Vijayakrishnan, Jacqueline M. Slavik, Zsolt Illés, Rebecca J. Greenwald, Dan Rainbow, Bernhard Greve, Laurence B. Peterson, David A. Hafler, Gordon J. Freeman, Arlene H. Sharpe, Linda S. Wicker, and Vijay K. Kuchroo

Autoimmune Disease-Associated CTLA-4 Splice Variant Lacking the B7 Binding Domain Signals Negatively in T Cells. Published in Immunity, Volume 20, Number 5, May 2004, pages 563-565. Source: EurekAlert.org (this is a press release).



Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg FibroSleep™ Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant Improvements in Memory, Learning, and Cognition.3 Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant Improvements in Memory, Learning, and Cognition.3
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Milk Thistle: Trusted Support for Health & Healing in a Toxic World Milk Thistle: Trusted Support for Health & Healing in a Toxic World
Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map