ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

Print Page
Email Article

Tiny Gene Changes Means Big Differences in Pain: Fibromyalgia News

  [ 261 votes ]   [ Discuss This Article ] • August 2, 2004

A 2003 study by US researchers has linked differences in the way people withstand pain - both physical and emotional stress - to a gene which makes a protein important for brain chemistry. The gene makes catechol-O-methyl transferase (COMT), an enzyme vital for mopping up the dopamine - a brain chemical linked with sensing pain. Tough guys and wimps carry different forms of the gene, according to Jon-Kar Zubieta and his team at the University of Michigan and The National Institute of Alcohol and Alcoholism, Rocksville, Maryland.

People with a particularly active form of COMT were hardier, whereas people with a less active form of COMT felt pain more acutely. Those with both forms of the gene, one from each parent, experienced intermediate pain. The COMT gene exists in two forms which make copies differing by a single amino acid only either valine or methionine. This small variation has a big effect on the activity of COMT, say the researchers. People with the laziest form of the gene - who have two copies of the methionine version - make enzymes three to four-fold less effective than the other variants containing just valine or one of each.

The team used brain imaging or positron emission tomography to examine the brain activity of 29 people who were subjected to a "tolerable" pain over 20 minutes. The volunteers were given a salt water injection into their jaw muscles to simulate a condition called temporomandibular joint pain disorder. They rated their own level of pain every 15 seconds during the brain imaging. Dr.Zubieta, the chief investigator predicted correctly that those people who were able to metabolise dopamine best because both copies of their gene were of the valine form would feel least pain. He said: "Depending on the genotype you have inherited there is a gradation in pain responsiveness. In people with two copies of the methionine form of COMT, the dopamine is not cleared fast enough. If this becomes chronic the uncleared dopamine starts to act on a second brain pathway regulating pain and stress". Based on these results one could predict that a quarter of the population would be pain sensitive types, a quarter would be more stoic types, and half would be in between. Source: news service

Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™ Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS
Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map