ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Vitamin D supplementation could ease IBS symptoms

Increase Your Magnesium Intake

Top Tips to Boost Your Immunity

11 Amazing Health Benefits of Using Baking Soda

Nicotinamide riboside shows promise for treatment of Alzheimer’s disease

Exercise, calcium, vitamin D, and other factors linked with fewer injurious falls

Vitamin D3 Is a Powerhouse for Your Heart

Rhodiola — A Powerful Adaptogen That Boosts Vitality and Performance, Eases Depression and Combats B...

Curcumin Supplementation May Impart Long-Term Cognitive Benefits

Vitamin D deficiency during pregnancy can program obesity in children

Print Page
Email Article

Genes May Determine Who Developed Gulf War Syndrome, University at Buffalo Researchers Find; Variant in ACE Gene Appears to Cause Susceptibility to Environmental Triggers

  [ 58 votes ]   [ Discuss This Article ] • August 10, 2004

By Ascribe, 8/10/2004 14:05 BUFFALO, N.Y., Aug. 10 (AScribe Newswire) --

Veterans of the first Persian Gulf War suffering from medically unexplained fatigue associated with Gulf War Syndrome may have a genetic predisposition for developing the condition, geneticists at the University at Buffalo have found. Their research, involving healthy veterans and veterans with severe and chronic fatigue, as well as non-veterans with chronic fatigue syndrome, showed that affected veterans, in comparison with healthy controls, had an increased frequency of a nonbeneficial genetic variant in a gene involved in the production of angiotension-converting-enzyme (ACE), an enzyme important in the control of blood pressure and electrolyte balance. Unexpectedly, the nonbeneficial variant was less common among non-veterans with symptoms identical to those of Gulf War Syndrome, indicating that the genetic variant rendered the carriers more susceptible to triggers present in the Gulf-War environment.

Results were reported in the July issue of Muscle and Nerve. ''The results of this study are somewhat controversial, because people don't necessarily want to accept the possibility of a genetic predisposition,'' said Georgirene Vladutiu, Ph.D., UB professor of pediatrics, neurology and pathology and first author on the study. ''The idea of something external as the cause is much more palatable.'' Vladutiu directs the Robert Guthrie Biochemical Genetics Laboratory at the Women and Children's Hospital of Buffalo and specializes in the laboratory diagnosis of metabolic muscle diseases. External or environmental factors do play a role in Gulf War Syndrome, said Vladutiu, but likely as triggers in those with a genetic predilection, rather than as the initial cause. ''These triggers may be extreme exertion, heat, chemical exposures, infections, multiple vaccinations, emotional stress and a combination of these conditions or something else entirely.'' ''We don't know if the triggers are specific to the first Persian Gulf War,'' she noted. ''Soldiers serving now are exposed to different environmental triggers. In addition, our sample is small. We need to prove or disprove these findings in a larger group of veterans from different theaters of war.''

Chronic fatigue manifests in two distinct forms. Unexplained fatigue with no other symptoms is diagnosed as idiopathic chronic fatigue (ICF). Fatigue accompanied by infections, painful joints or neuropsychiatric symptoms is called chronic fatigue syndrome (CFS). CFS/ICF is nearly four times as prevalent in veterans of the first Persian Gulf War as in non-veterans, earning the label Gulf War Syndrome in that population. CFS/ICF has been studied extensively, but the cause remains unknown.

Vladutiu and her colleague, Benjamin Natelson, M.D., at the War-Related Illness and Injury Study Center in Washington, D.C., and the CFS Cooperative Research Center at the UMDNJ- New Jersey Medical School, set out to determine if genetics may play a role. Earlier research had shown that persons with an insertion variant (added genetic material) of the ACE gene had higher endurance, appearing to derive a beneficial effect from the variant. Vladutiu theorized that persons with CFS would have a lower prevalence of the insertion variant with a correspondingly higher prevalence of the deletion variant (no added genetic material), which rendered them especially susceptible to a variety of environmental triggers that can bring on the muscle pain and reduced physical abilities characteristic of CFS/ICF. To test this theory, Vladutiu and Natelson analyzed DNA from banked blood samples from Gulf War veterans and non-veterans who were healthy or had CFS/ICF, looking for differences in the segment of the ACE gene that contains either the insertion or deletion of genetic material, called the I/D polymorphism. The possible combinations of the variants, known as genotypes, are II, ID, and DD. The II and ID genotypes are known to be beneficial, or at least not harmful, while the DD variant is believed to have a potentially negative impact on muscle function and has been associated with a number of other illnesses, such as multivessel cardiac disease, said Vladutiu.

The samples were collected from 49 Gulf War veterans with CFS, 61 non-veterans with CFS, 30 healthy veterans and 45 healthy non-veterans. Results of the genetic analysis showed that the frequency of the II genotype (beneficial) was significantly lower in veterans with Gulf-War Syndrome compared to healthy veterans, and both healthy and ill non-veterans. The II genotype was four times lower in the ill veterans than healthy veterans, results showed. Moreover, 76 percent of Gulf War veterans with the DD (nonbeneficial) genotype had CFS or ICF, compared with only 45 percent of veterans with the ID variant and 27 percent with the II variant. Those with the DD genotype were eight times more likely to have CFS/ICF than those with the II variant, results showed. ''Our genetic make-up determines how we respond to our environment in every sense of the word, including our interior environment,'' said Vladutiu. ''The lower prevalence of the II genotype and the increased prevalence of the DD genotype in Gulf War veterans with medically unexplained chronic fatigue points to an interaction between these genetic variants and some factor or factors specific to the Persian Gulf.''

The next step is to study these and other variants in the ACE gene in a larger group of affected and unaffected veterans of the first Gulf War, and compare the results with studies in veterans of the second Gulf War, as well as in veterans of other wars, such as in Bosnia and Vietnam, said Vladutiu. ''If the results of this study are reproducible in terms of the association with the ACE gene variant, then the stresses associated with war activity generally act as an external trigger on the function of a substance (ACE) that has multiple impacts on the physiology of the body.'' ''If the results show a specific association only in veterans of the first Gulf War,'' she said, ''then there was likely an environmental factor, such as one or more chemical exposures that, combined with variations in the ACE gene, predisposed certain individuals to the development of medically unexplained chronic fatigue.''

The research was supported by grants from the Muscular Dystrophy Association, the Children's Guild of Buffalo, UB, the Veterans Administration and the U.S. Public Health Service. CONTACT: John Della Contrada, University at Buffalo Media Relations, dellacon(at) or 716-645-5000, ext. 1409 The University at Buffalo is a premier research-intensive public university, the largest and most comprehensive campus in the State University of New York. UB's more than 27,000 students pursue their academic interests through more than 300 undergraduate, graduate and professional degree programs.

Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™

Article Comments

Be the first to comment on this article!

Post a Comment

Optimized Curcumin Longvida with Omega-3

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

The Fast-Acting Solution for Healthy Digestive Function The Fast-Acting Solution for Healthy Digestive Function
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Breakthrough Form of Magnesium Enhances Memory and Cognitive Function Breakthrough Form of Magnesium Enhances Memory and Cognitive Function
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
Prepare Yourself for Cold & Flu Season Prepare Yourself for Cold & Flu Season

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map