ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Study bodes well for low-carb eaters

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Omega Fix for Obesity: How the Right Fats Fight Fat

Potential of Quercetin in the Treatment of Melanoma

How Pomegranate May Protect Against Cancer

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Trimming the spare tire: Canola oil may cut belly fat

 
Print Page
Email Article

Researchers Find Genetic Link For Unexplained Chronic Fatigue

  [ 207 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 18, 2004


Genes May Determine Who Developed Gulf War Syndrome, University at Buffalo Researchers Find; Variant in ACE Gene Appears to Cause Susceptibility to Environmental Triggers BUFFALO, N.Y., Aug. 10 (Ascribe Newswire) --

Veterans of the first Persian Gulf War suffering from medically unexplained fatigue associated with Gulf War Syndrome may have a genetic predisposition for developing the condition, geneticists at the University at Buffalo have found. Their research, involving healthy veterans and veterans with severe and chronic fatigue, as well as non-veterans with chronic fatigue syndrome, showed that affected veterans, in comparison with healthy controls, had an increased frequency of a nonbeneficial genetic variant in a gene involved in the production of angiotension-converting-enzyme (ACE), an enzyme important in the control of blood pressure and electrolyte balance.

Unexpectedly, the nonbeneficial variant was less common among non-veterans with symptoms identical to those of Gulf War Syndrome, indicating that the genetic variant rendered the carriers more susceptible to triggers present in the Gulf-War environment. Results were reported in the July issue of Muscle and Nerve. ''The results of this study are somewhat controversial, because people don't necessarily want to accept the possibility of a genetic predisposition,'' said Georgirene Vladutiu, Ph.D., UB professor of pediatrics, neurology and pathology and first author on the study. ''The idea of something external as the cause is much more palatable.'' Vladutiu directs the Robert Guthrie Biochemical Genetics Laboratory at the Women and Children's Hospital of Buffalo and specializes in the laboratory diagnosis of metabolic muscle diseases. External or environmental factors do play a role in Gulf War Syndrome, said Vladutiu, but likely as triggers in those with a genetic predilection, rather than as the initial cause. ''These triggers may be extreme exertion, heat, chemical exposures, infections, multiple vaccinations, emotional stress and a combination of these conditions or something else entirely.'' ''We don't know if the triggers are specific to the first Persian Gulf War,'' she noted. ''Soldiers serving now are exposed to different environmental triggers. In addition, our sample is small. We need to prove or disprove these findings in a larger group of veterans from different theaters of war.''

Chronic fatigue manifests in two distinct forms. Unexplained fatigue with no other symptoms is diagnosed as idiopathic chronic fatigue (ICF). Fatigue accompanied by infections, painful joints or neuropsychiatric symptoms is called chronic fatigue syndrome (CFS). CFS/ICF is nearly four times as prevalent in veterans of the first Persian Gulf War as in non-veterans, earning the label Gulf War Syndrome in that population. CFS/ICF has been studied extensively, but the cause remains unknown. Vladutiu and her colleague, Benjamin Natelson, M.D., at the War-Related Illness and Injury Study Center in Washington, D.C., and the CFS Cooperative Research Center at the UMDNJ- New Jersey Medical School, set out to determine if genetics may play a role. Earlier research had shown that persons with an insertion variant (added genetic material) of the ACE gene had higher endurance, appearing to derive a beneficial effect from the variant. Vladutiu theorized that persons with CFS would have a lower prevalence of the insertion variant with a correspondingly higher prevalence of the deletion variant (no added genetic material), which rendered them especially susceptible to a variety of environmental triggers that can bring on the muscle pain and reduced physical abilities characteristic of CFS/ICF.

To test this theory, Vladutiu and Natelson analyzed DNA from banked blood samples from Gulf War veterans and non-veterans who were healthy or had CFS/ICF, looking for differences in the segment of the ACE gene that contains either the insertion or deletion of genetic material, called the I/D polymorphism. The possible combinations of the variants, known as genotypes, are II, ID, and DD. The II and ID genotypes are known to be beneficial, or at least not harmful, while the DD variant is believed to have a potentially negative impact on muscle function and has been associated with a number of other illnesses, such as multivessel cardiac disease, said Vladutiu. The samples were collected from 49 Gulf War veterans with CFS, 61 non-veterans with CFS, 30 healthy veterans and 45 healthy non-veterans. Results of the genetic analysis showed that the frequency of the II genotype (beneficial) was significantly lower in veterans with Gulf-War Syndrome compared to healthy veterans, and both healthy and ill non-veterans. The II genotype was four times lower in the ill veterans than healthy veterans, results showed. Moreover, 76 percent of Gulf War veterans with the DD (nonbeneficial) genotype had CFS or ICF, compared with only 45 percent of veterans with the ID variant and 27 percent with the II variant. Those with the DD genotype were eight times more likely to have CFS/ICF than those with the II variant, results showed.

''Our genetic make-up determines how we respond to our environment in every sense of the word, including our interior environment,'' said Vladutiu. ''The lower prevalence of the II genotype and the increased prevalence of the DD genotype in Gulf War veterans with medically unexplained chronic fatigue points to an interaction between these genetic variants and some factor or factors specific to the Persian Gulf.''

The next step is to study these and other variants in the ACE gene in a larger group of affected and unaffected veterans of the first Gulf War, and compare the results with studies in veterans of the second Gulf War, as well as in veterans of other wars, such as in Bosnia and Vietnam, said Vladutiu. ''If the results of this study are reproducible in terms of the association with the ACE gene variant, then the stresses associated with war activity generally act as an external trigger on the function of a substance (ACE) that has multiple impacts on the physiology of the body.'' ''If the results show a specific association only in veterans of the first Gulf War,'' she said, ''then there was likely an environmental factor, such as one or more chemical exposures that, combined with variations in the ACE gene, predisposed certain individuals to the development of medically unexplained chronic fatigue.''

The research was supported by grants from the Muscular Dystrophy Association, the Children's Guild of Buffalo, UB, the Veterans Administration and the U.S. Public Health Service. The University at Buffalo is a premier research-intensive public university, the largest and most comprehensive campus in the State University of New York. UB's more than 27,000 students pursue their academic interests through more than 300 undergraduate, graduate and professional degree programs.



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
Breaking Through the Mental Fog Breaking Through the Mental Fog

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map