ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Study bodes well for low-carb eaters

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Omega Fix for Obesity: How the Right Fats Fight Fat

Potential of Quercetin in the Treatment of Melanoma

How Pomegranate May Protect Against Cancer

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Trimming the spare tire: Canola oil may cut belly fat

 
Print Page
Email Article

New Brain Protein Regulates Sleep and Anxiety, UCI Study Finds

  [ 50 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 18, 2004


Source: University of California - Irvine

Findings point to a different way to treat sleep disorders and anxiety. UC Irvine pharmacology researchers have found how a recently discovered brain protein plays a major role regulating sleep and stress – a discovery that can lead to a new class of drugs for treating ailments ranging from sleep and anxiety disorders to attention deficit disorder.

The UCI team conducted tests to see how neuropeptide S (NPS) affected behavioral responses in rodents. They found that NPS increases alertness, suppresses sleep and even controls stress responses. This establishes NPS, which was first discovered in 2002, as an important modulator of sleep and alertness. This study also suggests NPS has potential as a target for new drugs to treat sleep disorders. The study appears in the Aug. 19 issue of Neuron.

"Since our knowledge of NPS is so new, we may be at the tip of the iceberg in understanding its function," said Rainer Reinscheid, assistant adjunct professor in pharmacology and lead researcher in the study. "We've found NPS to be so active with sleep and anxiety behavior that it can be a very attractive drug target, both to enhance and to suppress its function." In testing how NPS is involved with both sleep regulation and stress behaviors, the researchers found that NPS is produced by previously unidentified neurons in a brain stem region known for regulating arousal and anxiety. Further tests demonstrated that rats injected with NPS showed increased alertness and reduced slow-wave and REM sleep over untreated rats. NPS receptor proteins were also detected in stress-related brain regions such as the amygdala and thalamus. In behavior tests that measure their stress-related anxiety, mice injected with NPS show fewer anxiety responses and increased activity than untreated mice.

Sleep and fatigue are in a balance – insufficient sleep will increase fatigue, and only sleeping can reduce fatigue. There is a variety of sleep and fatigue disorders, which range from the most severe affecting only a set of individuals to mild ones nearly everyone will encounter. The most severe form of sleep disorder is narcolepsy, in which affected individuals suffer from irresistible sleep attacks. Most common is the excessive daytime sleepiness that may result from chronic sleep deprivation or sleep impairments. Very little is known about the basic mechanisms that regulate these physiological responses, but the UCI study provides a first glance at a neuropeptide that affects these sleep mechanisms.

"Some 100,000 Americans are currently treated for excessive daytime sleepiness, but the number of the undiagnosed is far larger," said study co-author Olivier Civelli, the Eric L. and Lila D. Nelson Chair in Neuropharmacology at UCI. "Furthermore, symptoms of sleepiness, often recognized as fatigue, are associated with numerous other illnesses, such as multiple sclerosis, Parkinson's disease and also depression. If it can be shown that the NPS system is a major modulator of fatigue, then its therapeutic potentials will be immense."

Yan-Ling Xu of UCI is a co-lead author on the study. Other participants are Stewart D. Clark, Zhiwei Wang, Steven H. Lin, Fernando A. Brucher, Joanne Zeng and Nga K. Ly of UCI; and Salvador Huitron-Resendiz, Steven J. Henriksen and Luis de Lecea of the Scripps Research Institute in La Jolla, Calif. The National Institutes of Health and the Stanley Medical Research Institute supported the research. UCI has applied for a patent for the pharmaceutical use of the NPS protein.

About NPS: NPS exerts its action by binding with a particular G protein-coupled receptor. GPRCs, as they are called, are a group of proteins that are the most important regulators of the central nervous system. Research on GPRCs has offered new insights into the understanding of particular brain functions and the receptors are popular targets for new drugs to treat a host of brain disorders. Experiments by the UCI team revealed that NPS is expressed discretely in a few brain areas. But its strongest expression is in a previously unidentified cluster of neurons located next to locus coeruleus (LC) neurons, a brain stem region known for regulating arousal and anxiety. LC neurons fire signals into the cerebral cortex to promote arousal and are inactive during periods of sleep. By identifying this new cluster of neurons, the UCI researchers have also begun to dissect the diverse functions attributed to the LC at an anatomical level, a discovery that will have major repercussions on the understanding of this brain area.

About the University of California, Irvine: The University of California, Irvine is a top-ranked public university dedicated to research, scholarship and community. Founded in 1965, UCI is among the fastest-growing University of California campuses, with approximately 24,000 undergraduate and graduate students and about 1,300 faculty members. The third-largest employer in dynamic Orange County, UCI contributes an annual economic impact of $3 billion.



Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra ATP+, Double Strength Energy NADH™ 12.5mg


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS
Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant Improvements in Memory, Learning, and Cognition.3 Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant Improvements in Memory, Learning, and Cognition.3
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map