ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

How One Tiny Molecule Turned into One Huge Health Breakthrough

Nutrients Boost Stem Cell Function

Humans have three times more brown body fat

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

How B Vitamins Improve Brain Health, Cognition, Psychiatric Problems and Mood Disorders

Dietary prebiotics improve sleep, buffer impacts of stress, says study

Exercises to Help Prevent Urinary Incontinence

Higher red blood cell omega 3 levels in women linked to lower risk of mortality over 14.9 year media...

Print Page
Email Article

Penn State Part of Multi-Institution Project to Study Restless Legs Syndrome

  [ 542 votes ]   [ Discuss This Article ] • September 23, 2004

Source: Penn State Announcement marks international Restless Legs Syndrome Awareness Day HERSHEY, PA-

A multi-institution research team including three Penn State scientists recently was awarded a $7.9 million grant from the National Institute on Aging of the National Institutes of Health to study the causes of and effectiveness of iron therapies to treat restless legs syndrome (RLS). The announcement today (Sept. 23) marks international Restless Legs Syndrome Awareness Day, which falls on the birthdate of RLS discoverer Karl Ekbom, a Swedish neurologist who first described the syndrome in the 1940s. The awareness day is meant to recognize RLS, an affliction that causes irresistible urges to move the legs and is often accompanied by creepy-crawly sensations in the legs. The sensations are only relieved by movement and become worse as the sun goes down, causing night after night of sleeplessness for the millions of people with RLS and their partners.

"This grant will make it possible for us to learn more about this syndrome and to begin to explore treatment options that may bring relief to sufferers," said James Connor, Ph.D., professor and vice chair for neurosurgery, Penn State Milton S. Hershey Medical Center, and co-investigator on the grant. "Together, this research team will be able to focus the varied expertise of its members to investigate causes of RLS while at the same time determining the effects of FDA-approved pharmaceuticals and iron therapies not indicated for, but used to help, those with RLS." Although its been long suspected that iron deficiency had something to do with RLS, in a previous study Connor and colleagues at Johns Hopkins University found that a specific receptor for iron transport is lacking in patients with RLS. When that mechanism malfunctions, enough iron gets to the brain to keep the cells alive, but not enough so that they function optimally. That missing iron may cause a misfiring to the legs creating the creepy-crawly feelings. Connor's work established a physical cause for the disorder and characterized it as a sensory motor rather than a psychological disorder.

The NIH grant, directed by principal investigator Christopher J. Earley, M.B., B.Ch., Ph.D., of Johns Hopkins Bayview Medical Center, will fund four separate projects. Connor's project will focus on further pinpointing the causes of RLS by obtaining a profile of the brains of RLS sufferers. Like his previous study, Connor will use tissue from the Restless Legs Syndrome Foundation's Harvard Brain Bank. This work will enable the team to more effectively develop and direct treatment strategies. John Beard, Ph.D., professor of nutritional sciences, and Byron Jones, Ph.D., professor of biobehavioral health and pharmacology, Penn State University, will explore how differences in the amount of iron in the brain relate to the functioning of the dopaminergic system, which is responsible for sending central nervous system signals to the body for controlling movement. Earley will lead two projects; one will focus on abnormalities in the central nervous system of people with RLS, and a second that will focus on the use of and effectiveness of intravenous iron supplementation as a potential long-term treatment for RLS. In addition, four core facilities - two at Johns Hopkins and two at Penn State University Park campus - will provide administrative, statistical, study recruitment, sample analysis and animal research support functions for the projects.

In addition to Connor, Beard, Jones and Earley, the study team includes: Richard Allen, Dean Wong, Suzanne Lesage, Peter Barker, Alena Horska, Jeff Bulte, Charles Rohde, and Juan Troncoso, Johns Hopkins University School of Medicine. For more information about RLS visit the RLS Foundation's Web site at For an appointment with an RLS specialist at Penn State Milton S. Hershey Medical Center, call 717-531-1441 or 800-292-3332. To participate in a clinical study on RLS, visit The Johns Hopkins Center for Restless Legs Syndrome Web site at

Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Optimized Curcumin Longvida® Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
How Glutathione Can Save Your Life How Glutathione Can Save Your Life
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
Carry a Massage Therapist in Your Pocket Carry a Massage Therapist in Your Pocket

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map