ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Artificial sweeteners linked to risk of weight gain, heart disease and other health issues

All About Ginkgo Biloba: Benefits of This Timeless Herbal Supplement

Yarrow Oil: Here's Why It Deserves a Place in Your First-Aid Kit

Vitamin D supplement use associated with lower risk of breast cancer

Carnitine deficiency suggested as contributor to autism

Lutein — An Important Nutrient for Eye and Brain Health

White Camphor Oil: The Purest Camphor Oil

Taurine: Facts About This Crucial Amino Acid

Lutein, found in leafy greens, may counter cognitive aging

Vitamin D3 Versus D2

 
Print Page
Email Article

New Therapy Under Development Improves Quality of Life in Patients Suffering From IBS

  [ 135 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 3, 2004


Source: American College of Gastroenterology Major new trial of Cilansetron shows promising results ORLANDO (November 1, 2004)-

-A new therapy under development for the treatment of irritable bowel syndrome with diarrhea predominance appears to provide significant improvements in measures of quality of life, according to a study presented at the 69th Annual Meeting of the American College of Gastroenterology. Cilansetron (Solvay Pharmaceuticals, Marietta, GA) is a novel 5-HT3 receptor antagonist.

Researchers Kevin W. Olden M.D., FACG of the University of South Alabama and Douglas A. Drossman, M.D., FACG of the University of North Carolina at Chapel Hill conducted a double-blind, placebo-controlled, 6-month multinational trial in which patients were randomized to cilansetron 2 mg three times a day or placebo. They gave participants a survey of IBS specific quality of life measures (IBS-QOL), developed by Dr. Drossman, at both the outset and the end of the study. Higher scores on IBS-QOL indicate better quality of life. The sample included 168 patients given cilansetron and 170 on placebo. At baseline, their mean overall IBS-QOL scores were 55.0 for cilansetron and 55.5 for placebo.

Overall, patients on cilansetron improved 17.7 on the scale compared to 9.6 for patients on placebo (p<0.005). Cilansetron showed statistically significant improvements for all subscales, except sexual, which showed the highest scores at baseline. The largest improvements were observed for interference with activity, food avoidance and poor mood (dysphoria), which had the lowest levels of QOL at baseline.

"These results show that cilansestron is well tolerated and efficacious in treating IBS with diarrhea in men and women," said Dr. Olden. "Cilansetron improves overall health- related quality of life and relieves specific symptoms of IBS with diarrhea." Both Dr. Olden and Dr. Drossman serve as consultants to Solvay, and their fellow researchers included employees of Solvay. The ACG was formed in 1932 to advance the scientific study and medical treatment of disorders of the gastrointestinal (GI) tract. The College promotes the highest standards in medical education and is guided by its commitment to meeting the needs of clinical gastroenterology practitioners.

EDITOR'S NOTE: This drug is not yet available to consumers. Here is a statement from the company that is developing it: "Cilansetron is a new compound developed by Solvay’s Research and Development Department. It is a selective 5HT3-antagonist which is in phase III clinical development for the indication of diarrhea predominant IBS. This means cilansetron is not yet on the market. The results from the first clinical studies are promising. We hope to tell you more about this product soon." For more information, please visit http://www.solvay-ibs.com/.



Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Ultra EPA  - Fish Oil Optimized Curcumin Longvida®


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map