ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

The Significance of Selenium

Print Page
Email Article

New Therapy Under Development Improves Quality of Life in Patients Suffering From IBS

  [ 135 votes ]   [ Discuss This Article ] • November 3, 2004

Source: American College of Gastroenterology Major new trial of Cilansetron shows promising results ORLANDO (November 1, 2004)-

-A new therapy under development for the treatment of irritable bowel syndrome with diarrhea predominance appears to provide significant improvements in measures of quality of life, according to a study presented at the 69th Annual Meeting of the American College of Gastroenterology. Cilansetron (Solvay Pharmaceuticals, Marietta, GA) is a novel 5-HT3 receptor antagonist.

Researchers Kevin W. Olden M.D., FACG of the University of South Alabama and Douglas A. Drossman, M.D., FACG of the University of North Carolina at Chapel Hill conducted a double-blind, placebo-controlled, 6-month multinational trial in which patients were randomized to cilansetron 2 mg three times a day or placebo. They gave participants a survey of IBS specific quality of life measures (IBS-QOL), developed by Dr. Drossman, at both the outset and the end of the study. Higher scores on IBS-QOL indicate better quality of life. The sample included 168 patients given cilansetron and 170 on placebo. At baseline, their mean overall IBS-QOL scores were 55.0 for cilansetron and 55.5 for placebo.

Overall, patients on cilansetron improved 17.7 on the scale compared to 9.6 for patients on placebo (p<0.005). Cilansetron showed statistically significant improvements for all subscales, except sexual, which showed the highest scores at baseline. The largest improvements were observed for interference with activity, food avoidance and poor mood (dysphoria), which had the lowest levels of QOL at baseline.

"These results show that cilansestron is well tolerated and efficacious in treating IBS with diarrhea in men and women," said Dr. Olden. "Cilansetron improves overall health- related quality of life and relieves specific symptoms of IBS with diarrhea." Both Dr. Olden and Dr. Drossman serve as consultants to Solvay, and their fellow researchers included employees of Solvay. The ACG was formed in 1932 to advance the scientific study and medical treatment of disorders of the gastrointestinal (GI) tract. The College promotes the highest standards in medical education and is guided by its commitment to meeting the needs of clinical gastroenterology practitioners.

EDITOR'S NOTE: This drug is not yet available to consumers. Here is a statement from the company that is developing it: "Cilansetron is a new compound developed by Solvay’s Research and Development Department. It is a selective 5HT3-antagonist which is in phase III clinical development for the indication of diarrhea predominant IBS. This means cilansetron is not yet on the market. The results from the first clinical studies are promising. We hope to tell you more about this product soon." For more information, please visit

Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Optimized Curcumin Longvida® Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Coconut Oil - Healthy Gifts from the 'Tree of Life' Coconut Oil - Healthy Gifts from the 'Tree of Life'
Eating Fat is Good... Maybe... Could Be... Sometimes Eating Fat is Good... Maybe... Could Be... Sometimes
Live Without Anxiety or Stress Live Without Anxiety or Stress
Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map