ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Coconut Oil Healthy? (The American Heart Association Doesn’t Think So)

American Heart Association Renders Itself Obsolete With 1960s Dietary Advice on Coconut Oil

How Fish Oil Benefits Heart Disease Patients with Depression

Ginger Fights Obesity

Health Benefits of Artichokes

Putting the Spotlight on Coriander Seed Oil

Migraines? Powdered Ginger May Help

Are Americans Really Getting Too Much Vitamin D? A Critical Look at Recent Media Warnings

Eating more vegetable protein may protect against early menopause

Vitamin C and antibiotics: A new one-two 'punch' for knocking-out cancer stem cells

 
Print Page
Email Article

Early Intervention Stops Damage to Insulin-Producing Cells In Women at High Risk for Type 2 Diabetes

  [ 22 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 17, 2002





SAN FRANCISCO, June 16, 2002 - Giving an anti-diabetes drug early to women at high risk for type 2 diabetes preserves the health of their insulin-producing cells better than postponing treatment until they actually develop the disease, according to a study from the Keck School of Medicine of USC.
Researchers presented the study at the American Diabetes Association's 62nd Scientific Sessions.

"The study has important implications for treatment strategies to prevent type 2 diabetes. It also helps define the primary cause of the disease: the failure of insulin-secreting cells caused by high insulin demands when the body?s tissues become resistant to its own insulin," says Thomas A. Buchanan, M.D., professor of medicine, obstetrics and gynecology and physiology and biophysics at the Keck School and the study?s lead author.

The Troglitazone in Prevention of Diabetes (TRIPOD) study previously found that using a drug to lessen insulin resistance could reduce the demands on beta cells- which secrete insulin in response to glucose- and prevent or slow type 2 diabetes onset in Latinas with recent gestational diabetes.

Although gestational diabetes usually disappears after childbirth, patients commonly remain resistant to their own insulin and 30 to 50 percent of them develop type 2 diabetes within a few years after pregnancy, Buchanan says. These women are considered at high risk for developing diabetes.

Buchanan and colleagues gave 121 young Latinas with recent gestational diabetes a daily dose of either troglitazone or a placebo. At that time, physicians nationwide commonly prescribed troglitazone to treat type 2 diabetes, because it helps the body's cells more effectively use insulin to absorb glucose. (The Food and Drug Administration recalled troglitazone in 2000, and USC researchers switched to prescribing pioglitazone, a similar-acting, FDA-approved drug in the ongoing study).

Any women in the placebo group who developed diabetes while participating in the study were switched to the anti-insulin-resistance drug. Thus, treatment in those women was begun later than in those who had taken the drug from the beginning of the study, before developing diabetes.

During the more than four years in which women were monitored, the group of 56 women who took the drug from the very start saw their insulin sensitivity and glucose tolerance tests remain stable. But among the 65 women who started on placebo, insulin sensitivity fell by 25 percent and acute insulin response fell by 39 percent. Glucose tolerance test levels rose by 10 percent, indicating growing levels of sugar in the blood.

When the researchers looked specifically at the group of women who originally received placebo, but were switched to troglitazone upon developing diabetes, they found that those women had an average decline in beta-cell function of 30 percent during the time they were developing diabetes while taking placebo. Once they developed diabetes and started taking the drug, the beta-cell decline stopped. Here is how it works:

When the body's muscle and fat cells grow resistant to insulin, the beta cells in the pancreas shift into overdrive to produce more insulin to compensate. Over time, this high workload causes beta cells to wear out in some people and produce less insulin, or stop altogether, causing type 2 diabetes. Buchanan and colleagues believe that lessening the workload might keep the beta cells from failing, thereby preventing diabetes. The results from this new analysis indicate that intervening early, before diabetes develops, saves about 30 percent more beta cells than can be saved if treatment is withheld until diabetes first develops.

Buchanan and colleagues are now furthering the research, seeking to understand why some peoples' beta cells wear out under high workloads, while others' do not.


Thomas Buchanan, Anny Xiang, Ruth Peters, Siri Kjos, Sylvia Tan, Aura Marroquin, Cesar Ochoa, Jose Goico and Stanley Azen, "Prevention of Type 2 Diabetes by Treatment of Insulin Resistance: Comparison of Early vs. Late Intervention in the TRIPOD Study," 62nd ADA Scientific Sessions, June 16. Category: Clinical Therapeutics. Abstract No. 140-OR.



Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Complete and Natural Menopause Relief Complete and Natural Menopause Relief
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map