ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

More evidence for calorie restriction’s longevity effect

A Little Zinc Goes a Long Way

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Get the Most From Your Green Tea

Iron (And More) For Lasting, Natural Energy

Affordable Care Act made cancer screening more accessible for millions, study finds

Metabolic syndrome increases the need for vitamin E

 
Print Page
Email Article

Gene Responsible for Most Malignant Melanomas is Discovered

  [ 39 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 24, 2002




By Mark Gould, London

Scientists working on the cancer genome project announced this week that they have made an "unexpectedly early" discovery of the mutant gene responsible for 70% of all malignant melanomas. The project, which is funded by the Wellcome Trust, is based at the Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire.

The researchers predict that the finding, which occurs in the early stages of a project involving 50 million experiments, will mean that the "vast majority" of the genes involved in the most common cancers will be identified within the next five years. The discovery is set to revolutionise cancer treatment, with the ability to target specific molecular abnormalities, they say.

The incidence of melanoma, which kills 1600 people a year in the United Kingdom and some 7400 in the United States, has doubled over the past decade. It is responsible for 11% of all skin cancers but almost all of the deaths from skin cancer because of its ability to metastasise rapidly.

The researchers, writing in the online version of Nature (www.nature.com), say that the mutation in the gene known as BRAF is "so clear cut" that they are five years away from offering drugs to block its action.

Scientists on the project began work in February 2001 to identify which of the 30000 human genes are involved in cancer. Professor Mike Stratton, one of the leaders of the project, said that the BRAF mutation was one of the first 20 they looked at.

"Because mutated BRAF is permanently `on,' we have already started searching for drugs that will switch it back off," Professor Stratton said. He said that slow computers were hampering progress to identify all the genetic components of all cancers.

But Professor Stratton said the consensus was that not all cancers shared one common genetic mutation. Project co-leader Dr Andy Futreal said that 1000 different human cancer samples, representing 43 different types of cancer, had been studied and that the initial results were "quite striking."

"Amongst the 2200 odd letters that go to encode the BRAF protein, one of those accounted for about 80% of all the mutations found. A single change, from a T to an A, in the spelling of the BRAF sequence will account for the mutation. It's extraordinarily specific."

The T to A switch in BRAF is also found in ABL, a gene found in myeloid leukaemia. This has been successfully treated with the new generation of tyrosine kinase inhibitors, such as imatinib (Glivec). The Wellcome Trust has now patented the gene to facilitate research on new treatments.

Source: BMJ 2002;324:1412 ( 15 June )




Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Energy NADH™ 12.5mg Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
Eating Fat is Good... Maybe... Could Be... Sometimes Eating Fat is Good... Maybe... Could Be... Sometimes
When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map