ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Coconut Oil Healthy? (The American Heart Association Doesn’t Think So)

American Heart Association Renders Itself Obsolete With 1960s Dietary Advice on Coconut Oil

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?

Health Benefits of Artichokes

Putting the Spotlight on Coriander Seed Oil

Migraines? Powdered Ginger May Help

Are Americans Really Getting Too Much Vitamin D? A Critical Look at Recent Media Warnings

Eating more vegetable protein may protect against early menopause

Is Activated Charcoal Beneficial?

German Chamomile Oil: A Versatile Essential Oil You Should Have at Home

 
Print Page
Email Article

Yale Researchers Shed Light on B Cells' Involvement in Autoimmune Diseases like Lupus

  [ 32 votes ]   [ Discuss This Article ]
www.ProHealth.com • October 1, 2002


YALE News Release

CONTACT: Karen N. Peart 203-432-1326, #44

For Immediate Release: September 25, 2002

New Haven, Conn. -- Using genetically altered mice, Yale researchers have generated a clearer picture of the origins of B cells and their involvement in autoimmune diseases such as lupus, rheumatoid arthritis and diabetes.

Published in the September 20 issue of Science, the study, led by Mark Shlomchik, M.D., associate professor of laboratory medicine at Yale School of Medicine, looked at B cells' reactions to its own toxins, known as antigens. B lymphocyte cells normally produce antibodies to viruses and bacteria, which protect against infection. However, when these antibodies are directed toward the body's own components they are called "autoantibodies," which can cause inflammation and autoimmune disease.

"B cells that react with 'self' antigens (autoreactive B cells) are very important in the origins of these autoimmune diseases," said Shlomchik. "These B cells make autoantibodies, and also stimulate white blood cells called autoreactive T lymphocytes that destroy tissues, such as the kidney, joints and skin which are the major organs affected in Lupus and Rheumatoid Arthritis." In normal individuals these B cells are tightly controlled and prevented from making autoantibodies.

Shlomchik said the scientific community has known for 15 years that autoantibodies undergo the same processes that generate memory immune responses to viruses. The most important of these processes is called somatic hypermutation, which refers to changes in the genetic code that produces the antibodies. As a result, every immune response contains many subtle variations that critically increase the breadth and strength of the response. There is no other similar process in any cell in mammals, and in B cells it is thought to occur normally in a unique site called the germinal center. However, until now no one had shown where autoantibodies were generated.

The researchers used a strain of mice that were prone to autoimmune diseases to visualize autoreactive B cells. They found that the autoantibody reaction does not take place in the germinal center as previously thought, but in an unusual area of the spleen. The team also demonstrated that somatic hypermutation of autoantibodies occurs outside of the germinal center in this unusual part of the spleen. These findings suggest that in lupus and other autoimmune diseases, B cells that create autoantibodies escape normal controls by proliferating and undergoing somatic hypermutation outside of the germinal center, which is the normal location for these processes.

Other authors on the study included Jacqueline William and Sean Christensen, both MD/Ph.D. students at Yale; and Chad Euler who was a research technician in the Shlomchik lab.



Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® FibroSleep™ Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Inflammation Disrupts Memory - What Can You Do to Protect Your Brain? Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?
Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones
Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar
Breaking Through the Mental Fog Breaking Through the Mental Fog

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map