ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Scientifically-designed fasting diet lowers risks for major diseases

More evidence for calorie restriction’s longevity effect

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

Get the Most From Your Green Tea

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Acupuncture boosts effectiveness of standard medical care for chronic pain, depression

Iron (And More) For Lasting, Natural Energy

Metabolic syndrome increases the need for vitamin E

Supplement combo improves bone density, mood, in postmenopausal women

 
Print Page
Email Article

Duloxetine Reduces Fibromyalgia Pain: Presented at the Annual Meeting of the American Academy of Pain Management

  [ 933 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 1, 2006


By Crystal Phend
Source: Doctor's Guide News SAN DIEGO, CA -- February 27, 2006 -- The antidepressant duloxetine (Cymbalta) appears effective in treating pain and improving quality of life compared to placebo in women with fibromyalgia, researchers said here February 23rd at the 22nd Annual Meeting of the American Academy of Pain Management (AAPM). "There are no approved drugs for fibromyalgia," said presenting author Michael J. Detke, MD, PhD, medical director for Cymbalta at Lilly Research Laboratories, Indianapolis, Indiana. "It's a significant medical problem." Although the same serotonin and norepinephrine systems responsible for depression are dysfunctional in patients with fibromyalgia, Dr. Detke said duloxetine's pain-relieving effect appears independent from its effect on mood. The researchers presented two randomized, placebo-controlled, double-blind studies of women with fibromyalgia according to the American College of Rheumatology criteria and significant pain (an intensity of at least 4 on the Fibromyalgia Impact Questionnaire or Brief Pain Inventory). Twenty-five to 40% of the patients had a current major depressive disorder and all baseline characteristics were similar between treatment arms. In the first study, 92 women received 60 mg of duloxetine twice daily while another 92 received placebo. In the second study, 118 were randomized to 60 mg of duloxetine once daily, 116 to a dose of 60 mg twice daily, and another 120 to placebo. Average pain scores were significantly lower by about 1 point in both studies for the duloxetine groups compared with placebo, but there was no difference between once and twice daily dosing groups in the second study. Both studies showed significantly greater percentages of patients achieving a 50% reduction in pain on duloxetine versus placebo, which Dr. Detke called a "pretty robust" finding. Fatigue and rest scores showed similar significant reductions in the second study for duloxetine versus placebo. The reductions were not significant in the first study. Patients with and without major depressive disorder experienced the same significant reduction in pain compared to placebo. No significant interaction between pain alleviation and depression was found in either study. The authors concluded that duloxetine was safe and effective in treating fibromyalgia pain. [Presentation title: Duloxetine in the Treatment of Fibromyalgia in Women -- Results from Two Clinical Trials. Poster 144] Copyright (c) 1995-2006 Doctor's Guide Publishing Limited



Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor® Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
Break Free From Fibromyalgia Break Free From Fibromyalgia
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map