ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

Scientifically-designed fasting diet lowers risks for major diseases

How One Tiny Molecule Turned into One Huge Health Breakthrough

Acupuncture boosts effectiveness of standard medical care for chronic pain, depression

Research on Astaxanthin Demonstrates Significant Whole Body Benefits

Humans have three times more brown body fat

Nutrients Boost Stem Cell Function

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

Dietary prebiotics improve sleep, buffer impacts of stress, says study

 
Print Page
Email Article

Abstract: Perceptual wind-up in the human oesophagus is enhanced by central sensitisation

  [ 328 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 1, 2006


Gut. 2006 Feb 21; [Epub ahead of print] Sarkar S, Woolf CJ, Hobson AR, Thompson DG, Aziz Q. Hope Hospital & University of Manchester, United Kingdom. BACKGROUND: Oesophageal acid infusion induces enhanced pain hypersensitivity in non-acid exposed upper oesophagus (secondary hyperalgesia) in NCCP patients, thus suggesting central sensitization contributes to visceral pain hypersensitivity in functional gut disorders (FGD). Perceptual wind up (WUP) (increased pain perception to constant intensity sensory stimuli at frequencies>/= 0.3Hz) is used as a proxy for central sensitization to investigate pain syndromes where pain hypersensitivity is important e.g. fibromyalgia. AIMS: WUP in central sensitization induced human visceral pain hypersensitivity has not been explored. Hypothesis; if WUP is a proxy for central sensitization induced human visceral pain hypersensitivity, then oesophageal WUP should be enhanced by secondary hyperalgesia. METHODS: In 8 healthy volunteers (7 male; mean age 32 years), perception at pain threshold (PT) to a train of 20 electrical stimuli applied to the hand & the upper oesophagus (UE) at either 0.1Hz (control) or 2Hz was determined before and 1-hour following a 30-minute lower oesophageal acid infusions. RESULTS: WUP occurred only with the 2Hz train in the UE and hand (Both p=0.01). Following acid infusion, PT decreased (17+4%; p=0.01) in UE, suggesting the presence of secondary hyperalgesia. WUP to the 2Hz train increased in the UE (WUP ratio; 1.4+0.1 to 1.6+0.1; p=0.03) but not the hand (WUP ratio; 1.3+0.1 & 1.3+0.1; p=0.3). CONCLUSION: The enhanced WUP after secondary oesophageal hyperalgesia suggests that visceral pain hypersensitivity induced by central sensitization, results from increased central neuronal excitability. WUP may offer new opportunities to investigate the contribution of central neuronal changes to symptoms in FGD. PMID: 16492716 [PubMed - as supplied by publisher]




Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Ultra EPA  - Fish Oil Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
"It's Not Easy Being Green" - But It Is Healthy

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map