ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Discover Why Ashwagandha Can Be Used for Stress and Anxiety

How Can You Benefit From Vitamin B12?

Calorie restriction promotes longevity through effects on mitochondrial network

A spoonful of oil: Fats and oils help to unlock full nutritional benefits of veggies, study suggests

Lower magnesium levels linked with increased mortality risk during up to 40 years of follow-up

Higher resveratrol dose linked to lower glucose levels in type 2 diabetics

What Is Bitter Orange?

Black Tea Is Great for Your Gut

Drug can dramatically reduce weight of people with obesity

Tryptophan's Possible Effects for Your Health

 
Print Page
Email Article

Abstract: Perceptual wind-up in the human oesophagus is enhanced by central sensitisation

  [ 328 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 1, 2006


Gut. 2006 Feb 21; [Epub ahead of print] Sarkar S, Woolf CJ, Hobson AR, Thompson DG, Aziz Q. Hope Hospital & University of Manchester, United Kingdom. BACKGROUND: Oesophageal acid infusion induces enhanced pain hypersensitivity in non-acid exposed upper oesophagus (secondary hyperalgesia) in NCCP patients, thus suggesting central sensitization contributes to visceral pain hypersensitivity in functional gut disorders (FGD). Perceptual wind up (WUP) (increased pain perception to constant intensity sensory stimuli at frequencies>/= 0.3Hz) is used as a proxy for central sensitization to investigate pain syndromes where pain hypersensitivity is important e.g. fibromyalgia. AIMS: WUP in central sensitization induced human visceral pain hypersensitivity has not been explored. Hypothesis; if WUP is a proxy for central sensitization induced human visceral pain hypersensitivity, then oesophageal WUP should be enhanced by secondary hyperalgesia. METHODS: In 8 healthy volunteers (7 male; mean age 32 years), perception at pain threshold (PT) to a train of 20 electrical stimuli applied to the hand & the upper oesophagus (UE) at either 0.1Hz (control) or 2Hz was determined before and 1-hour following a 30-minute lower oesophageal acid infusions. RESULTS: WUP occurred only with the 2Hz train in the UE and hand (Both p=0.01). Following acid infusion, PT decreased (17+4%; p=0.01) in UE, suggesting the presence of secondary hyperalgesia. WUP to the 2Hz train increased in the UE (WUP ratio; 1.4+0.1 to 1.6+0.1; p=0.03) but not the hand (WUP ratio; 1.3+0.1 & 1.3+0.1; p=0.3). CONCLUSION: The enhanced WUP after secondary oesophageal hyperalgesia suggests that visceral pain hypersensitivity induced by central sensitization, results from increased central neuronal excitability. WUP may offer new opportunities to investigate the contribution of central neuronal changes to symptoms in FGD. PMID: 16492716 [PubMed - as supplied by publisher]




Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Energy NADH™ 12.5mg Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Help for Soreness and Swelling: What Do Silkworms Have to Do With It? Help for Soreness and Swelling: What Do Silkworms Have to Do With It?
Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask
Can Pomegranates Slow Aging? Can Pomegranates Slow Aging?
How I Found My Long-Lost Energy How I Found My Long-Lost Energy
Physically and Mentally Exhausted? How to Restore Energy at Its Source Physically and Mentally Exhausted? How to Restore Energy at Its Source

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map