ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

The Significance of Selenium

Print Page
Email Article

Two Studies Find Gray Matter Reduction in CFS Patients

  [ 539 votes ]   [ Discuss This Article ] • March 8, 2006

Source: The Science & Research of CFS, The CFIDS Chronicle Special Issue, 2005-2006. Just released, this issue is generating huge buzz in the CFS community. Copies are available through the CFIDS Association’s website at for $12 each. Visit to browse a complete listing of articles, including links to several online samples. Cognitive difficulties are found in 85-95% of CFS patients. Now, cutting-edge research from two independent international groups suggests that the volume of gray matter in the brain is significantly decreased in CFS. This decrease in brain tissue, or cerebral atrophy, may be responsible for cognitive problems in some people with CFS. The most recent of the studies, conducted in 2005 in the Netherlands, used MRI technology to measure brain volume and tissue concentration, finding that the volume of gray matter in CFS patients was significantly decreased. What is especially interesting about this study is that after researchers found structural abnormalities in a first CFS cohort, they repeated the experiment in a second cohort of equal size and found the same results. In all, 28 patients and 28 healthy controls were tested. The researchers, led by Floris de Lange, report that when results from both cohorts were combined, the reduction in gray matter tissue in CFS patients was 8%. This echoes the 2004 findings of a Japanese research group led by Tomohisa Okada, M.D., Ph.D., which observed "a significant reduction in gray matter volume in the bilateral prefrontal areas of CFS patients." Investigators found an 11.8% volume reduction in the 16 CFS patients compared to the 49 healthy controls. Both studies used a technique called voxel-based morphometry (VBM) to measure the results of the brain scan. Unlike assessment techniques that rely on human observers and rating scales, VBM is an automated procedure that provides unbiased results. While gray matter reduction was found in both studies using VBM, neither study found white matter abnormalities. Although we don't know if the observed cerbral atrophy is a cause of CFS or a consequence, these findings are alarming some members of the CFS patient community, who are concerned about "brain damage." It's important to note that the studies are small and need to be replicated by other researchers before definite conclusions can be made. And even if the results are confirmed by future investigators, the brain has a remarkable ability to adapt and rewire itself in compensatory ways [depending on the severity of the damage]. Research shows that people with CFS may use more extensive regions of the brain to process tasks and information, perhaps compensating for deficits in specific areas of the brain. There are rehabilitative techniques patients can employ to help with cognitive problems. Reprinted with kind permission of the CFIDS Association of America, that nation's largest non-profit organization dedicated to Chronic Fatigue Syndrome. Online at

Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Vitamin D3 Extreme™ Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map