ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

How One Tiny Molecule Turned into One Huge Health Breakthrough

Nutrients Boost Stem Cell Function

Humans have three times more brown body fat

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

How B Vitamins Improve Brain Health, Cognition, Psychiatric Problems and Mood Disorders

Dietary prebiotics improve sleep, buffer impacts of stress, says study

Ylang Ylang Oil Not Only Soothes Your Skin, but Your Mind as Well

Exercises to Help Prevent Urinary Incontinence

Print Page
Email Article

Dietary Supplement Improves Energy at the Cellular Level

  [ 97 votes ]   [ Discuss This Article ]
By Editor • • July 25, 2006

Chronic Fatigue Syndrome (CFS) and “chronic fatigue” are not interchangeable terms. So a 2004 clinical trial report indicating that dietary supplementation with NT Factor® supported significant average quality-of-life (energy) improvements for some trial subjects with chronic fatigue didn’t quite cut it. Now, the research has been expanded to include data on a clinical trial involving only patients with CFS and/or Fibromyalgia (FM). And the findings are comparable. The new report, published in the August 2006 issue of the Journal of Chronic Fatigue Syndrome, is based on three trials. In each trial, the individuals receiving the proprietary dietary supplement NT Factor® over periods of two to three months achieved “significant” average improvements in energy. The researchers – Drs. Garth Nicolson and Rita Ellithorpe, both with the nonprofit Institute for Molecular Medicine – explicitly state they have no financial interest in NT Factor®. Approach and results. All study subjects completed the 27-question Piper Fatigue Scale as a measure of energy both before the trial (at baseline) and after completing the trial. A comparison of these measures indicated the following average improvements in energy:
  • 40.5 percent for the first group, which included 34 cancer patients with baseline moderate to severe fatigue associated with cell damage in chemotherapy. Their average age was 50.
  • 35.5 percent for the second group, composed of 20 subjects with baseline moderate to severe chronic fatigue associated with the aging process. Their average age was 69, the oldest was over 90.
  • 43.1 percent average increase in energy for subjects in the CFS/FM trial, which included 15 diagnosed subjects, also with moderate to severe fatigue at baseline. Their average age was 45.
These energy-improvement data are statistically significant, ranging from P < 0.0001 to P < 0.0001. This means the probability that they are owing to chance is less than one in 1,000. The mechanisms involved. Cell function is highly complex, but basically Drs. Nicolson and Ellithorpe cite more than 50 research reports indicating the following. The membranes of cells, and of structures within the cells such as the mitochondria (energy-generators) act as the “gatekeepers,” determining which materials will be allowed to enter or exit the membrane. When damaged by free radicals, which are associated with stresses such as infection, aging, and CFS/FM, for example, the mitochondria become “leaky” (like a rusted metal container), and can allow damaging chemicals into the cell and valuable nutrients out. The researchers explained that “at the biochemical level, fatigue is related to the metabolic energy available to tissues and cells, mainly through mitochondrial electron transport. Thus the integrity of mitochondrial membranes is critical to cell function and energy metabolism. The failure to repair or replace these damaged molecules at a rate that exceeds their damage results in impaired mitochondrial function.” The researchers further said that “Fatigue is related to cellular energy systems found primarily in the cells’ mitochondria. Damage to mitochondrial components, mainly by ROS (Reactive Oxygen Species, or free radicals) oxidation, can impair their ability to produce high-energy molecules such as ATP and NADH. This occurs naturally with aging and during chronic illnesses, where the production of ROS can cause oxidative stress and cellular damage, resulting in oxidation of lipids [fatty acids], proteins and DNA.” NT Factor® works with a unique dual protective and replacement action. The antioxidants in the formula help to reduce the current rate of damage by free radicals, and to replenish and strengthen the body’s natural protective systems. The antioxidants also protect the fatty acids in the formula from oxidative damage until they can enter the circulatory system. The unique fatty acids in the formula are the specific types utilized in cell membranes, and they actually replace the damaged oxidized fatty acids in the membranes of cells and inter-cellular structures like the mitochondria. This allows the cells to be restored to their normal fluidity, permeability, and function. The researchers noted that such Lipid Replacement Therapy (LRT) “is not just the dietary substitution of certain lipids with proposed health benefits; it is the actual replacement of damaged cellular lipids with undamaged lipids to insure proper structure and function of cellular tissues.” The study showed that the restoration of cellular energy function took place over an 8- to 12-week period, but that continued supplementation at a maintenance level was required to maintain the energy improvement. “Disease and infection can result in oxidative damage that exceeds the abilities of cellular systems to repair and replace damaged molecules, and this is also the case in fatiguing illnesses” said the researchers. Dietary supplementation to maintain cellular structure and energy function is an important lifestyle action for improved quality of life. The new report, “Lipid Replacement and Antioxidant Nutritional Therapy for Restoring Mitochondrial Function and Reducing Fatigue in Chronic Fatigue Syndrome and Other Fatiguing Illnesses,” by Garth L. Nicolson, PhD, and Rita Ellithorpe, MD, was published in the August 2006 issue of the Journal of Chronic Fatigue Syndrome, at To read the earlier report, published with the same title in 2004 and including the same explanations minus only the CFS/FM study data, go to the archives.

Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra ATP+, Double Strength Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
Top 3 Nutrients to Detox the Liver and Soothe Digestion Top 3 Nutrients to Detox the Liver and Soothe Digestion
How Glutathione Can Save Your Life How Glutathione Can Save Your Life
The Super Antioxidant for Brain, Joint and Heart Health The Super Antioxidant for Brain, Joint and Heart Health
Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map