ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Ultrasound Therapy for Fibromyalgia and Lyme Disease

Curcumin: The All In One Solution, Part 2

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Why You Should Take Your Apple Cider Vinegar at Night

Use Burdock Oil to Promote Healthy Hair Growth

Meet Your Weight Loss Goals

AMA journal associates iron deficiency with hearing loss

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

Lutein linked to preservation of crystallized intelligence

 
Print Page
Email Article

Columbia University Researchers Discover On/Off Switch for Chronic Pain

  [ 919 votes ]   [ Discuss This Article ]
By Editor • www.ProHealth.com • August 8, 2006


Researchers at Columbia University in New York have identified a protein in nerve calls that acts as an “on/off switch for chronic pain.” They’ve applied for patents to develop a new class of drugs that they predict will block chronic pain by turning this switch off.

The “switch” is the enzyme protein kinase G (PKG), which is activated upon injury or inflammation. And, the researchers state, “we are very optimistic that this discovery and our continued research will ultimately lead to a novel approach to pain relief for the millions suffering from chronic pain.”

Scientists have known for years that for chronic pain to persist, “a master switch must be turned on” inside the first order or peripheral nerve cells. These are the neurons that feed from the body to the second order nerve cells in the spinal cord, responsible in turn for relaying pain messages to the brain.

Pain becomes chronic when the peripheral neurons continue to send pain messages even after damaged cells heal or inflammation in the tissue subsides. The pain switch does not turn off. But until now the identity of that switch in the peripheral neurons remained a mystery.

The discovery is important because previous approaches to alleviating chronic pain have focused on using drugs to damp the activity of the spinal cord neurons. That has proved hard to accomplish, because the drugs need to overcome the blood-brain barrier, which is a physical membrane that selectively controls passage of substances from the blood into the brain to protect and maintain a “stable brain environment.”

Further, the Columbia researchers note, none of the existing pharmaceutical drugs on the market are adequate to deal with chronic pain. “Cox-2 inhibitors carry severe risk of side effects, opioids are highly addictive, Tylenol is ineffective for chronic pain, and other pain drugs cause significant drowsiness,” they stated.

The article explaining this discovery, “Activation and retrograde transport of protein kinase G in rat nociceptive neurons after nerve injury and inflammation,” by Y.J. Sung, et al., was published in the August 2006 issue of the journal Neuroscience.



Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Ultra ATP+, Double Strength Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root
Health Benefits Are Brewing in Green Tea Health Benefits Are Brewing in Green Tea
Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map