ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Curcumin: The All In One Solution, Part 2

CoQ10 — A Nutritional Powerhouse for Mitochondrial Health

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Use Burdock Oil to Promote Healthy Hair Growth

Why You Should Take Your Apple Cider Vinegar at Night

AMA journal associates iron deficiency with hearing loss

Lutein linked to preservation of crystallized intelligence

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

Zinc eaten at levels found in biofortified crops reduces 'wear and tear' on DNA

 
Print Page
Email Article

Symptom Relief of Major Depression in Less Than Two Hours with Experimental Medication

  [ 421 votes ]   [ Discuss This Article ]
By Editor • www.ProHealth.com • August 25, 2006


A single very low intravenous dose of a medication historically employed for anesthesia – and experimentally for FM pain – can provide significant relief or remission of treatment-resistant major depression in less than two hours, according to a new study by the National Institute of Mental Health. Further, for 35 percent of the patients, the response to the single dose was sustained for at least one week. The patients who took part in this randomized, placebo-controlled, double-blind crossover trial had previously tried an average of six antidepressants without symptom relief.

These findings have potentially “enormous public health implications,” according to the NIMH. By comparison, most currently-used antidepressants require eight weeks to demonstrate benefits – if they work at all – for patients diagnosed with treatment-resistant major depression. And usually four to six weeks are required even for “more responsive” patients, the researchers explain.

The drug involved - Ketamine - corrects a chemical imbalance in the brain that interferes with the regulation of normal electrical flow between brain cells. It is able to act so much more swiftly than other antidepressants because it intervenes in the same mood-regulating chemical chain of events as they do, only several stages “downstream.”

However, because Ketamine has become known in club-drug circles for its “psychedelic” side effects since the 1960s, the NIMH researchers caution that an altered version of the drug will be necessary for use as an antidepressant, to avoid addiction or disorientation. And in the process, they believe, they’ll come closer to understanding why depression occurs in the first place – while possibly identifying biological markers that may aid in diagnosis.

The report on the NIMH trial, “A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression,” by Carlos A. Zarate, Jr., MD, et al., was published in the August 2006 issue of the Archives of General Psychiatry. See also the NIMH press release at www.nimh.nih.gov/press/ketamine.cfm

Implications regarding the mechanism of Fibromyalgia pain. In technical terms, Ketamine’s antidepressant quality is thought to result from its ability to block the brain protein N-methyl-D-aspartate (NMDA) receptor. Researchers believe that this same “NMDA antagonist” action may account for Ketamine’s ability to reduce some Fibromyalgia patients’ pain and tender point sensitivity, as demonstrated in various trials.1,2 The inference is that Fibromyalgia pain may result from “NMDA receptor activation in the spinal cord” – causing an increase in the neurons’ response to pain stimuli (“central sensitization”).3

_____

1. Go to the ImmuneSupport.com archive http://www.immunesupport.com/library/showarticle.cfm/id/2554/searchtext/ketamine to find an abstract of the article “Pain analysis in patients with Fibromyalgia (FM). Effects of intravenous morphine, lidocaine, & ketamine,” by J. Sorenson, et al., published in the November-December 1995 issue of the Scandinavian Journal of Rheumatology.

2. Go to the Immune Support.com archive http://www.immunesupport.com/library/showarticle.cfm/id/5209/searchtext/ketamine to find an abstract of the article “Ketamine in chronic pain management: An evidence-based review,” by G. Hocking & M.J. Cousins, published in the December 2003 issue of the journal Anesthesia and Analgesia.

3. Go to http://opioids.com/nmda/receptor.html to review an abstract of the article “Update on the neurophysiology of pain transmission and modulation: Focus on the NMDA-Receptor,” by G.J. Bennett, published in the January 2000 issue of the Journal of Pain Symptom Management.




Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Energy NADH™ 12.5mg Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Safely Burn Away Body Fat Safely Burn Away Body Fat
Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map