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Shortened QT interval: a distinctive feature of the dysautonomia of Chronic Fatigue Syndrome.

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By Jochanan Naschitz, MD [a, *], Madeline Fields, MD [a], Hillel Isseroff, MD [a], Dauod Sharif, MD [b], Edmond Sabo, MD [a], Itzhak Rosner, MD [c] • www.ProHealth.com • August 30, 2006


Journal: J Electrocardiol. [In Press Corrected Proof] available online 2006 Feb 28; [Epub ahead of print] Authors: Jochanan Naschitz, MD [a, *], Madeline Fields, MD [a], Hillel Isseroff, MD [a], Dauod Sharif, MD [b], Edmond Sabo, MD [a], Itzhak Rosner, MD [c] Received 9 September 2005 published online 27 February 2006. Corrected Proof Affiliations: [a] Department of Internal Medicine A, Bnai Zion Medical Center and 'Rappaport Family' Faculty of Medicine, Technion-Israel Institute of Technology, P.O. Box 4940, Haifa 31048, Israel [b] Heart Institute, Bnai Zion Medical Center and 'Rappaport Family' Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31048, Israel [c] Department of Rheumatology, Bnai Zion Medical Center and 'Rappaport Family' Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31048, Israel [*] Corresponding author. E-mail: naschitz@tx.technion.ac.il NLM Citation: PMID: 16895768 PURPOSE: Because autonomic nervous functioning is frequently abnormal in chronic fatigue syndrome (CFS), we examined whether the corrected QT interval (QTc) in CFS differs from QTc in other populations. METHODS: The QTc was calculated at the end of 10 minutes of recumbence and the end of 10 minutes of head-up tilt. In a pilot study, groups of 15 subjects, CFS, and controls, matched for age and sex, were investigated. In a second phase of the study, the QTc was measured in larger groups of CFS (n = 30) and control patients (n = 96) not matched for demographic features. RESULTS: In the pilot study, the average supine QTc in CFS was 0.371 +/- 0.02 seconds and QTc on tilt, 0.385 +/- 0.02 seconds, significantly shorter than in controls (P = .0002 and .0003, respectively). Results of phase II confirmed this data. CONCLUSIONS: Relative short QTc intervals are features of the CFS-related dysautonomia. The significance of this finding is discussed.




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