ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

15 Health Benefits of Chia Seeds, According to Science

Tangerine Oil: A Citrusy Essential Oil With Well-Rounded Uses

Magnesium Deficiency Raises Your Risk of Many Chronic Ailments

Resveratrol supplementation improves arterial stiffness in type 2 diabetics

CoQ10's Potential Capabilities for Your Health

Testosterone replacement therapy associated with improved urinary, sexual function

How Can Melatonin Benefit You?

Cloves: Boost Your Immune System the Sweet and Spicy Way

The Many Potential Health Benefits of Curcumin

8 Chia Seed Recipes

 
Print Page
Email Article

UK Researchers Apply for CFS “Diagnosis and Treatment” Patent

  [ 583 votes ]   [ Discuss This Article ]
By Editor • www.ProHealth.com • October 18, 2006


Dr. John W. Gow - a much-published neurobiologist who until recently led genetic research work on ME/CFS at the University of Glasgow in Scotland - has moved as of August 2006 to Glasgow Caledonian University, where he continues research addressing what he believes to be the unique “gene signature” of patients with ME/CFS.

The UK-based ME Association, a nonprofit organization that was instrumental in raising private-donor monies to support continuation of Dr. Gow’s research when its funding ran out, has encouraged donors to consider requesting that unspent donations be transferred to support his projects at Glasgow Caledonian University.

The patent application. Also in mid-August 2006, Dr. Gow and his fellow researcher at the University of Glasgow, Dr. Abhijit Chaudhuri, submitted an application to the European Patent Office for “a diagnostic tool for CFS.” The “invention” they wish to patent involves “materials and methods for diagnosis and treatment of CFS.” These are based on the genetic biomarkers for CFS that the two applicants have described in the course of their ongoing research – what they have termed “the gene signature” for ME/CFS.

The abstract of their application states:

The invention relates to materials and methods for diagnosis and treatment of chronic fatigue syndrome/myalgic encephalitis. A number of genes are identified which are expressed at abnormal levels in patients affected by CFS/ME as compared to normal healthy individuals. These genes include those encoding defensin a1, haemoglobin ?, CXCR4, tubulin beta 1, serine/threonine kinase 17B, HLA DRss4 and prostaglandin D2 synthase. The genes identified provide objective disease markers that may be used in diagnostic tests to support the diagnosis of CFS/ME or for monitoring the effectiveness of therapy. They also provide a rational basis for classifying CFS/ME patients according to the biochemical lesion [usually referring to a tissue abnormality] underlying their symptoms and enable provision of appropriate targeted therapies.

A very detailed description of the concepts underlying this patent application - complete with tables - is available at the European Patent Office Website.* But some key concepts seem to be that:
n The data produced by the materials and methods described might not by itself support “an absolute diagnosis of CFS,” but could help confirm or rule out a physician’s preliminary diagnosis based on physical or psychological symptoms.
n The idea is that if one or more of the genes the researchers have associated with CFS is “upregulated” - shows “at least a two-fold increase in expression” versus its expression in an unaffected individual – then a diagnosis of CFS would be likely. And if these genes are not upregulated, CFS might be ruled out.
n The doctors postulate that CFS is not a disease caused by inherited gene defects, but is an “acquired condition” involving changes in certain genes associated with infection, immunity, and “cell membrane function and cell cycle.”
n They believe they’ve observed what they call a “hub” and “network” relationship in the gene expression of CFS patients. The hub genes being like “control centers” and the network genes the hubs’ “implementers,” affecting a range of biological shifts or symptoms in CFS patients. Identification of different patterns might offer clues as to targeted therapies.

In reporting on this patent application, the CFIDS Association of America has noted that, because processing of patent applications averages four years in Europe, Drs. Gow and Chaudhuri will likely continue refining their knowledge – as will the other research groups involved in CFS genetic analysis around the world.

An abstract of a presentation that Dr. Gow gave in 2005 outlining the genetic analysis leading up to this patent application is included in the ImmuneSupport.com CFS abstracts listing. The presentation, titled “Whole-Genome (33,000 genes) Affymetrix DNA Microarray Analysis of Gene Expression in Chronic Fatigue Syndrome,” was featured at the International Conference on Fatigue Science in Karuizawa, Japan in February 2005.

______

* Full information about Drs. Gow and Chadhuri’s patent application is available at the European Patent Office Website http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006082390&F=0




Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida® Ultra ATP+, Double Strength


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You
Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
Enhance Eyelashes Naturally Enhance Eyelashes Naturally
Guarding Against the Dangers of Vitamin D Deficiency Guarding Against the Dangers of Vitamin D Deficiency

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map