ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is a Good Night's Sleep at the Top of Your Wishlist?

Ashwagandha Helps Hormones - Aids Arthritis

Why You Should Be Eating More Porcini Mushrooms

A Breathalyzer for Disease?

Tryptophan's Possible Effects for Your Health

How Bacopa Can Help Improve Your Cognitive Function

Black Tea Is Great for Your Gut

Magnesium Reduces Diabetes and Helps Keep You Young

Lavender Aromatherapy Can Ease Pre-Op Anxiety

Mint: Learn More About This Refreshing and Invigorating Herb

 
Print Page
Email Article

New Horizons of Nerve Repair

  [ 172 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 22, 2002





Biomedical engineer trips up proteins in nerve regeneration system

It's sticky, it's a gel, it comes in a tube, but this is no greasy kids' stuff. Rather, it's a novel delivery system for peripheral nerve regeneration that could have implications for successful stem cell delivery and spinal cord repair.

Shelly Sakiyama-Elbert, Ph.D., assistant professor of biomedical engineering at Washington University in St. Louis, has designed a system that employs a nerve guide tube filled with a gel containing growth factor proteins that stimulate nerve regeneration. Also part of the package are strategically placed sugars and peptides for binding in the gel matrix. The system has promoted peripheral nerve regeneration in preliminary rat studies.

The clinical Gold Standard for peripheral nerve regeneration involves taking a nerve from a donor site on the injured person's body and sewing the donor nerve in between the two ends of the injured nerve. Though the nerve is dead, it provides a pathway that can guide the regeneration of the injured nerve. This is problematic because it creates an injury to be addressed at the donor site, and there is a limit to the amount of donor tissue you can use from a patient. Furthermore, there is no guarantee that the donated nerve will come to life in a new site. Another alternative is the use of cadaver nerves, which runs a risk of rejection.

Sakiyama-Elbert, working with famed plastic surgeon Susan Mackinnon ,M.D., Syd. M. and Robert H. Shoenberg Professor of Surgery of the Washington University Medical School, places exogenous sticky material capable of binding growth factors throughout the gel, causing the growth factor proteins to remain in the gel for months because they keep tripping over the sticky material. These binding sites can be tuned according to how fast the drug needs to be released for successful regeneration. Timed release is a key component of her system, because a real limitation is having the proteins diffuse out in a day or two, which is the case with many currently used systems.

Sakiyama-Elbert recently presented these results at a conference hosted by the Plastic Surgery Research Council, April 18-20, in Boston. Her work is sponsored by the Whitaker Foundation.

Another approach to peripheral nerve regeneration that Sakiyama-Elbert is testing involves creating her own protein consisting of a growth factor, and two different domains, a cross-linking site and a substrate for an enzyme that cleaves the growth factor at just the time a regenerating nerve cell would be migrating through the matrix. This cell-activated drug delivery system is also incorporated into a gel and delivered from a nerve guide tube, and it's a great example of a new area known as biologically responsible materials.

Stem cells for spinal cord repair

She also is one of very few researchers looking into matrixes for spinal cord damage, such as the kind that actor Christopher Reeves suffered years ago and from which he is not recovered. She is collaborating with John McDonald, M.D., Ph.D., assistant professor of neurobiology at the Washington University School of Medicine. McDonald already has treated spinal cord injuries in rats with embryonic stem cells; the problem is that most of the stem cells died after transplantation. Sakiyama-Elbert is hopeful that her matrix/tube delivery system will allow 50 to 75 percent survival of the stem cells by providing a more hospitable environment for the cells immediately after transplantation.

"The overall goal of this direction of my research is to apply novel bioengineering technology to allow controlled release of growth factors from scaffolds that facilitate the regeneration of adult spinal cord axons through and beyond spinal cord lesions," Sakiyama-Elbert said. "The scaffolds are drug-delivery systems consisting of protein matrices containing growth factors that are released in a sustained manner during tissue regeneration."

The scaffolds can be further modified by adding embryonic stem cells during polymerization, a process where small molecules are combined together to form larger ones.

"The embryonic stem cells can repopulate the injured spinal cord and serve as a source of nerve growth factors during regeneration," Sakiyama-Elbert explained.



Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil FibroSleep™ Ultra ATP+, Double Strength


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
How I Found My Long-Lost Energy How I Found My Long-Lost Energy
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map