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5-HT in the Enteric Nervous System: Gut Function and Neuropharmacology

  [ 182 votes ]   [ 1 Comment ]
By Peter G. McLean, et al • • December 13, 2006

Journal: Trends in Neurosciences. 2006 Nov 24; [E-publication ahead of print]

[Note: A large population study found 63% of Chronic Fatigue Syndrome patients had Irritable Bowel Syndrome, versus 22% of the population overall. 5-HT is serotonin, a “neurotransmitter” chemical involved in transmitting impulses between nerve cells. It is formed in the brain and mostly found in the brain, digestive tract lining, and blood platelets.]

Authors and affiliation: Peter G. McLean, Richard A. Borman, Kevin Lee. Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Harlow, Essex, UK. [E-mail: ] PMID: 17126921

In recent times, the perception of functional gastrointestinal disorders such as irritable bowel syndrome (IBS) has shifted fundamentally. Such disorders are now thought of as serious diseases characterized by perturbations in the neuronal regulation of gastrointestinal function. The concept of visceral hypersensitivity, the characterization of neuronal networks in the “brain-gut axis” and the identification of several novel 5-HT-mediated mechanisms have contributed to this shift.

Here, we review how some of the more promising of these new mechanisms (for example, those involving 5-HT transporters and the 5-HT(2B), 5-HT(7) and putative 5-HT(1p) receptors) might lead to a range of second-generation therapies that could revolutionize the treatment of functional gastrointestinal disorders, particularly IBS.

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Article Comments Post a Comment

more details please re: conclusion of the article .
Posted by: keybard
Dec 13, 2006
can't recall what second generation refers to, in pharmaceutical context.
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