ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Discover Why Ashwagandha Can Be Used for Stress and Anxiety

How Can You Benefit From Vitamin B12?

Calorie restriction promotes longevity through effects on mitochondrial network

Lower magnesium levels linked with increased mortality risk during up to 40 years of follow-up

Higher resveratrol dose linked to lower glucose levels in type 2 diabetics

What Is Bitter Orange?

Black Tea Is Great for Your Gut

Drug can dramatically reduce weight of people with obesity

Tryptophan's Possible Effects for Your Health

New Finding: Broccoli Helps Heal Leaky Gut

 
Print Page
Email Article

Review of Ampligen® clinical trials in Chronic Fatigue Syndrome

  [ 315 votes ]   [ 1 Comment ]
By W. Mitchell • www.ProHealth.com • January 17, 2007


Journal: Journal of Clinical Virology, Vol. 37, Supplement I, December 2006, pg. S113. [Sponsored by HHV-6 Foundation. E-Publication Jan 2007. Full text available for a fee at http://www.sciencedirect.com/science/journal/13866532 ] Author and affiliation: W. Mitchell. Chronic Fatigue Syndrome Clinical Consortium, Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN, USA; Hemispherx Biopharma, Philadelphia, PA, USA. [E-mail: bill.mitchell@vanderbilt.edu ]

Objectives: Ampligen is a double-stranded (ds) RNA with well established broad antiviral and immunomodulatory properties that has been studied extensively in the treatment of Chronic Fatigue Syndrome (CFS). A total of five open-label and two double-blind, placebo-controlled trials have enrolled over 750 subjects. Primary endpoints have been achieved with statistical significance. No serious safety issues have resulted from the administration of ~75,000 doses IV (most commonly 400 mg) twice weekly for up to one year periods or greater. Animal toxicity studies support this observation in humans with primates demonstrating the greatest margin of safety.

In the recently completed Phase 3 trial, patients receiving Ampligen for 40 weeks improved exercise treadmill performance 14.8% compared to the placebo group (p = 0.025) and 12.9% by intent to treat analysis (p = 0.052), and this improvement represents twice the minimum considered medically significant (6.5%). The Ampligen cohort with Baseline exercise duration >9 min improved oxygen utilization compared to a decrease in the placebo group (p < 0.05). Increased oxygen utilization correlated significantly with improved treadmill exercise duration (p < 0.001). The KPS, as a function of general physical capacity, was similarly significantly correlated (p = 0.01) with the improvement in exercise tolerance of the Ampligen study arm.

Summary:
n Patients with CFS use large quantities of drugs to alleviate the symptoms associated with CFS. The concomitant use of drugs to treat symptoms of CFS was significantly less in the Ampligen arms of both the Phase 2 and Phase 3 controlled trials.
n Ampligen treatment in chronically debilitated CFS populations has demonstrated significant improvement in physical well being and quality of life that can be linked with dysregulation of gene expression associated with energy metabolism.
n The improvement in exercise duration is significantly correlated to improvement in oxygen utilization and physical performance.




Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil Energy NADH™ 12.5mg


Article Comments Post a Comment

"Full text" of article for purchase is no more than what you see
Posted by: Wisty
Jun 4, 2009
Don't buy the "full text" of this article, which is available from the link near the top. For $31.50, you will get a pdf copy of the actual journal page. But the "full text" of the article -- which really is an abstract of a presentation made at a conference -- is exactly the text posted above. Rip off!
Reply Reply
 
Optimized Curcumin Longvida with Omega-3

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
Prepare Yourself for Cold & Flu Season Prepare Yourself for Cold & Flu Season
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map