ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fighting Heartburn and Gerd Naturally – And Safely!

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Natural Bladder Control, Go Less and Live More

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Trimming the spare tire: Canola oil may cut belly fat

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

Curcumin Reverses the Cellular Damage of Chronic Stress

The Onion: Cancer Fighter and Food Preserver

Probiotics improve cognition in Alzheimer's patients

 
Print Page
Email Article

Infection and Vaccination in Chronic Fatigue Syndrome: Myth or Reality?

  [ 290 votes ]   [ Discuss This Article ]
By S Appel, et al. • www.ProHealth.com • March 23, 2007


Journal: Autoimmunity. 2007 Feb;40(1):48-53.

Authors and affiliation: Appel S, Chapman J, Shoenfeld Y. Department of Neurology, Sheba Medical Center, Hashomer Israel.

PMID: 17364497

Chronic Fatigue Syndrome (CFS) is characterized by severe disabling fatigue lasting for more than 6 months associated with physical and mental disturbances such as headache, arthralgia, myalgia, memory impairment, sore throat and tender lymph nodes. The exact pathogenesis is still unknown.

Several models were proposed to explain its etiology including chronic infection, endocrine dysfunction, autonomic imbalance, depression, decreased immunity states and an aberrant reaction to infection. No convincing evidence was found to support any of the suggested pathogenic mechanisms.

The current concept is that CFS pathogenesis is a multi factorial condition in which an infective agent causes an aberrant immune response characterized by a shift to Th-2 dominant response. When the response fails to be switched-off, a chronic immune activation occurs and clinically expressed as the symptomatology of CFS.

Vaccinations are used in order to stimulate the immune system to induce a persistent immunity against the favorable antigens. Several syndromes that contain chronic fatigue as one of their symptoms, such as "Gulf War Syndrome" and macrophagic myofasciitis, were related to vaccinations.

Can vaccinations induce the aberrant immune response of CFS? Little is known about this issue. There are some reports on CFS occurring after vaccination, but few prospective and retrospective studies failed to find such an association.

A working group of the Canadian Laboratory Center for Disease Control (LCDC) that was founded in order to examine the suspected association between CFS and vaccinations concluded that there is no evidence that relates CFS to vaccination. Further studies are requested to examine this issue since it is very conceivable that if infection can lead to CFS, vaccination may also lead to it in the same immune-mediated pathogenesis.

Keywords: Chronic fatigue syndrome, infection, vaccination, Th-2 immune response

_____
References:

Steele, L and Dobbins, JG and Fukuda, K and Reyes, M and Randall, B and Koppel man, M and Reeves, WC. (1998) The epidemiology of chronic fatigue in San Francisco Am J Med, 105, pp. 83S - 90S.

Straus, SE. (1988) The chronic mononucleosis syndrome J Infect Dis, 157, pp. 405 - 412.

Fukuda, K and Straus, S and Hickie, I and Sharpe, M and Dobbins, J and Komaroff, A. (1994) The chronic fatigue syndrome: A comprehensive approach to its definition and study Ann Intern Med, 121, pp. 953 - 959.

Sharpe, M and Archard, LC and Banatvala, JE. (1991) A report chronic fatigue syndrome: Guidelines for research J R Soc Med, 84, pp. 118 - 121.

Poteliakhoff, A. (1981) Adrenocortical activity and some clinical findings in chronic fatigue J Psychosom Res, 25, pp. 91 - 95.

Moorkens, G and Berwaerts, J and Wynants, H and Abs, R. (2000) Characterization of pituitary function with emphasis on GH secretion in the chronic fatigue syndrome Clin Endocrinol (Oxf), 53, pp. 99 - 106.

Cleare, AJ and Blair, D and Chambers, S and Wessely, S. (2001) Urinary free cortisol in chronic fatigue syndrome Am J Psychiatry, 158, pp. 641 - 643.

Cleare, AJ and Miell, J and Heap, E and Sookdeo, S and Young, L and Malhi, GS and O'Keane, V. (2001) Hypothalamopituitaryadrenal axis function in chronic fatigue syndrome, and the effects of low-dose hydrocortisone therapy J Clin Endocrinol Metab, 86, pp. 3545 - 3554.

Cleare, AJ and Heap, E and Malhi, GS and Wessely, S and O'Keane, V and Miell, J. (1999) Low-dose hydrocortisonee in chronic fatigue syndrome: A randomised crossover trial Lancet, 353(6), pp. 455 - 458.

Scott, LV and Svec, F and Dinan, T. (2000) A preliminary study of dehydroepiandrosterone response to low-dose ACTH in chronic fatigue syndrome and in healthy subjects Psychiatry Res, 97, pp. 21 - 28.

Kuratsune, H and Yamaguti, K and Sawada, M and Kodate, S and Machii, T and Kanakura, Y and Kitani, T. (1998) Dehydroepiandrosterone sulfate deficiency in chronic fatigue syndrome Int J Mol Med, 1, pp. 143 - 146.

Moorkens, G and Wynants, H and Abs, R. (1998) Effect of growth hormone treatment in patients with chronic fatigue syndrome: A preliminary study Growth Horm IGF Res, 8, pp. 131 - 133.

Kennedy, G and Spence, V and Underwood, C and Belch, JJ. (2004) Increased neutrophil apoptosis in chronic fatigue syndrome J Clin Pathol, 57, pp. 891 - 893.

Patarca, R. (2001) Cytokines and chronic fatigue syndrome Ann N Y Acad Sci, 933, pp. 185 - 200.

Gerrity, TR and Bates, J and Bell, DS and Chrousos, G and Furst, G and Hedrick, T and Hurwitz, B and Kula, RW and Levine, SM and Moore, RC and Schondorf, R. (2002/2003) Chronic fatigue syndrome: What role does the autonomic nervous system play in the pathophysiology of this complex illness? Neuroimmunomodulation, 10, pp. 134 - 141.

Naschitz, JE and Yeshurun, D and Rosner, I. (2004) Dysautonomia in chronic fatigue syndrome: Facts, hypotheses, implications Med Hypotheses, 62, pp. 203 - 206.

Zachrisson, O and Colque-Navarro, P and Gottfries, CG and Regland, B and Mollby, R. (2004) Immune modulation with a staphylococcal preparation in fibromyalgia/chronic fatigue syndrome: Relation between antibody levels and clinical improvement Eur J Clin Microbiol Infect Dis, 23, pp. 98 - 105. Epub 2004 January 20

Prins, JB and Bleijenberg, G and Bazelmans, E and Elving, LD and de Boo, TM and Severens, JL and van der Wilt, GJ and Spinhoven, P and van der Meer, JW. (2001) Cognitive behaviour therapy for chronic fatigue syndrome: A multicentre randomised controlled trial Lancet, 357(9259), pp. 841 - 847. 17

Gold, D and Bowden, R and Sixbey, J and Riggs, R and Katon, WJ and Ashley, R and Obrigewitch, R and Corey, L. (1990) Chronic fatigue: A prospective clinical and virologic study JAMA, 264, pp. 48 - 53.

Natelson, BH and Haghighi, MH and Ponzio, NM. (2002) A review of the evidence on the presence of immune dysfunction in chronic fatigue syndrome Clin Diagn Lab Immunol, 9, pp. 747 - 752.

Lerner, AM and Dworkin, HJ and Sayyed, T and Chang, CH and Fitzgerald, JT and Beqaj, S and Deeter, RG and Goldstein, J and Gottipolu, P and O'Neill, W. (2004) Prevalence of abnormal cardiac wall motion in the cardiomyopathy associated with incomplete multiplication of Epstein-barr virus and/or cytomegalovirus in patients with chronic fatigue syndrome In Vivo, 18, pp. 417 - 424.

Ablashi, DV and Eastman, HB and Owen, CB and Roman, MM and Friedman, J and Zabriskie, JB and Peterson, DL and Pearson, GR and Whitman, JE. (2000) Frequent HHV-6 reactivation in multiple sclerosis (MS) and chronic fatigue syndrome (CFS) patients J Clin Virol, 16, pp. 179 - 191.

Soto, NE and Straus, SE. (2000) Chronic fatigue syndrome and herpesviruses: The fading evidence Herpes, 7, pp. 46 - 50.

Lane, RJ and Soteriou, BA and Zhang, H and Archard, LC. (2003) Enterovirus related metabolic myopathy: A postviral fatigue syndrome J Neurol Neurosurg Psychiatry, 74, pp. 1382 - 1386.

Galbraith, DN and Nairn, C and Clements, GB. (1997) Evidence for enteroviral persistence in humans J Gen Virol, 78, pp. 307 - 312.

Straus, SE. (1996) Chronic fatigue syndrome BMJ, 313(5), pp. 831 - 832.

Swanink, CM and Melchers, WJ and van der Meer, JW and Vercoulen, JH and Bleijenberg, G and Fennis, JF and Galama, JM. (1994) Enteroviruses and the chronic fatigue syndrome Clin Infect Dis, 19, pp. 860 - 864.

Kerr, JR and Bracewell, J and Laing, I and Mattey, DL and Bernstein, RM and Bruce, IN and Tyrrell, DA. (2002) Chronic fatigue syndrome and arthralgia following parvovirus B19 infection J Rheumatol, 29, pp. 595 - 602.

McGhee, SA and Kaska, B and Liebhaber, M and Stiehm, ER. (2005) Persistent parvovirus-associated chronic fatigue treated with high dose intravenous immunoglobulin Pediatr Infect Dis J, 24, pp. 272 - 274.

Nijs, J and Nicolson, GL and De Becker, P and Coomans, D and De Meirleir, K. (2002) High prevalence of Mycoplasma infections among European chronic fatigue syndrome patients. Examination of four Mycoplasma species in blood of chronic fatigue syndrome patients FEMS Immunol Med Microbiol, 34(15), pp. 209 - 214.

Endresen, GK. (2003) Mycoplasma blood infection in chronic fatigue and fibromyalgia syndromes Rheumatol Int, 23, pp. 211 - 215. Epub 2003 July 16

MacDonald, KL and Osterholm, MT and LeDell, KH and White, KE and Schenck, CH and Chao, CC and Persing, DH and Johnson, RC and Barker, JM and Peterson, PK. (1996) A case-control study to assess possible triggers and cofactors in chronic fatigue syndrome Am J Med, 100, pp. 548 - 554.

Schutzer, SE and Natelson, BH. (1999) Absence of Borrelia burgdorferi-specific immune complexes in chronic fatigue syndrome Neurology, 53(6), pp. 1340 - 1341. October 12

Gustaw, K. (2003) Chronic fatigue syndrome following tick-borne diseases Neurol Neurochir Pol, 37, pp. 1211 - 1221. NovemberDecember Grayston, JT and Grayston, JT. (1992) Infections caused by Chlamydia pneumoniae strain TWAR Clin Infect Dis, 15(5), pp. 757 - 761. November

Chia, JK and Chia, LY. (1999) Chronic Chlamydia pneumoniae infection: A treatable cause of chronic fatigue syndrome Clin Infect Dis, 29, pp. 452 - 453.

Nicolson, GL and Gan, R and Haier, J. (2003) Multiple co-infections (Mycoplasma, Chlamydia, human herpes virus-6) in blood of chronic fatigue syndrome patients: Association with signs and symptoms APMIS, 111, pp. 557 - 566.

Komaroff, AL and Wang, SP and Lee, J and Grayston, JT. (1992) No association of chronic Chlamydia pneumoniae infection with chronic fatigue syndrome J Infect Dis, 165, pp. 184.

Rottem, M and Shoenfeld, Y. (2004) Vaccination and allergy Curr Opin Otolaryngol Head Neck Surg, 12, pp. 223 - 231.

Molina, V and Shoenfeld, Y. (2005) Infection, vaccines and other environmental triggers of autoimmunity Autoimmunity, 38, pp. 235 - 245.

Schattner, A. (2005) Consequence or coincidence? The occurrence, pathogenesis and significance of autoimmune manifestations after viral vaccines Vaccine, 23(10), pp. 3876 - 3886.

Haley, R and Kurt, T. (1997) Self-reported exposure to neurotoxic chemical combinations in Gulf war JAMA, 277, pp. 231 - 237. [CrossRef] Rook, G and Zumla, A. (1997) Gulf war syndrome: Is it due to a systemic shift in the cytokine balance towards a Th 2profile? Lancet, 349, pp. 1831 - 1833.

Hotopf, M and David, A and Hull, L and Ismail, K and Unwin, C and Wessely, S. (2000) Role of vaccinations as risk factor for ill health in veterans of the Gulf war: Cross sectional study BMJ(320), pp. 1363 - 1367.

Gherardi, RK and Authier, FJ. (2003) Aluminum inclusion macrophagic myofasciitis: A recently identified condition Immunol Allergy Clin North Am, 23, pp. 699 - 712.

Alleged link between hepatitis B vaccine and chronic fatigue syndrome CMAJ, 1461 1992. p 1145.

Duclos, P. (2003) Safety of immunisation and adverse events following vaccination against hepatitis B Expert Opin Drug Saf, 2, pp. 225 - 231.

Zuckerman, JN. (2006) Protective efficacy, immunotherapeutic potential, and safety of hepatitis B vaccines J Med Virol, 78, pp. 169 - 177.

Sleigh, KM and Marra, FH and Stiver, HG. (2002) Influenza vaccination: Is it appropriate in chronic fatigue syndrome? Am J Respir Med, 1, pp. 3 - 9.





Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra EPA  - Fish Oil Optimized Curcumin Longvida®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
"It's Not Easy Being Green" - But It Is Healthy
Safely Burn Away Body Fat Safely Burn Away Body Fat

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map