ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

How One Tiny Molecule Turned into One Huge Health Breakthrough

Nutrients Boost Stem Cell Function

Humans have three times more brown body fat

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

How B Vitamins Improve Brain Health, Cognition, Psychiatric Problems and Mood Disorders

Dietary prebiotics improve sleep, buffer impacts of stress, says study

Ylang Ylang Oil Not Only Soothes Your Skin, but Your Mind as Well

Exercises to Help Prevent Urinary Incontinence

 
Print Page
Email Article

Researchers Identify Key Molecular Mechanism in Rheumatoid Arthritis

  [ 1 vote ]   [ Discuss This Article ]
By News Release • www.ProHealth.com • January 9, 2000


CHAPEL HILL, N.C. - A study at the University of North Carolina at Chapel Hill has identified a novel molecular mechanism in cell proliferation.

The study published Sept. 2 in the journal "Nature" shows that a molecular switch, transcription factor NF-kappaB, has a pivotal role in the regulation of cell growth and death. The new findings shed new light on tumor development. "Signaling pathways regulating cell growth and death are intrinsically linked to each other. Proliferating cells die unless specific growth factors are present. This provides a built-in protection against cancer. When this protection fails, cell proliferation runs out of control," says Dr. Sergei S. Makarov, research assistant professor of medicine at the UNC-CH School of Medicine and Thurston Arthritis Research Center. "Because of that, it is so important to understand the molecular mechanisms that control cell death and proliferation."

In the "Nature" report, Makarov and co-author Dr. Julia A. Romashkova detail a kind of molecular tango linking NF-kappaB with a trio of proto-oncogenes: Myc, Akt, and Ras. "Ras, Akt, and Myc are essential players in growth factor signaling," Makarov says. "They relay the signals required for proliferation. We found that NF-kappaB links the actions of these proteins."
The new findings are based on biochemical assays of cultured cells. The researchers show that after stimulation with growth factors, NF-kappaB becomes activated through an intricate sequence of molecular signals -- protein-to-protein relays -- involving Ras and Akt. The activation of NF-kappaB, in turn, leads to the expression of a protein called c-Myc -- a central regulator of cell growth, death, and differentiation.

"We know that c-Myc is essential for proliferation," Makarov says. "However, c-Myc causes cell death when it is over-expressed. In the presence of growth factors, c-Myc becomes not lethal but proliferative. How the growth factors regulate the functions of c-Myc, has not been clear," Makarov says. "When we blocked NF-kappaB activation, growth factors did not work against c-Myc-induced death.

Otherwise, activated NF-kappaB itself was able to prevent the lethal effects of c-Myc overexpression. This meant that the growth factors induce proliferation and inhibit cell death through NF-kappaB activation."

Although the study dealt with normal cells, the results have implications for understanding abnormal proliferation of tumor cells. Mutations in Ras, Akt, and Myc are found in a vast majority of human tumors. Similar to that, NF-kappaB activation is a frequent feature of tumor cells. The molecular mechanism also may apply in rheumatoid arthritis. Previous studies by Makarov's laboratory and others show that over-expression of c-Myc and activation of NF-kappaB is associated with tissue changes characteristic of the disease: inflammation and the overgrowth of synovial cells lining the joint capsule.
"Rheumatoid arthritis and tumors have lots in common," Makarov says. "You have uncontrollable growth in both. You also have over-expression of c-Myc and activation of NF-kappaB."

"These findings underscore NF-kappaB as a very attractive molecular target in the development of cancer and arthritis therapeutics," he adds.

Source: University



Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You
Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map