ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

The Significance of Selenium

Print Page
Email Article

New Cancer Drug Possible From Compound Found in Common Food

  [ 10 votes ]   [ Discuss This Article ] • August 21, 2002

A compound found in many foods and drinks could form the basis for new drugs to defeat cancer and heart disease, scientists at UCL claimed today.

Professor Peter Shepherd and his team believe that caffeine and theophylline- compounds commonly found in cola beverages, coffee, tea and chocolate - block the operation of a key enzyme linked to a wide range of cell functions. This suggests these compounds would block cell growth and also blood clotting. The teams work may also explain the anti-inflammatory properties of theophylline, a drug used for many years in asthma treatment.

The enzyme, PI-3 Kinase, is thought by scientists to play a key role in the signalling mechanism which determines cell growth and death. The particular form of the enzyme targeted by caffeine - called p110 delta -was also recently found by another UCL team for being responsible for orchestrating the human body's response to infection and to be potentially involved in the development of irritable bowel disease.

Operating deep within the cell, PI-3 Kinase stimulates phosphates to be attached onto a particular lipid sited within the membrane of the cell. This process triggers the signalling pathways which ultimately control cell growth, movement and survival.

In the studies, genetically engineered insect cells were used to produce p110delta and a standard biochemical test was conducted to establish if phosphates had indeed attached to lipids. Interestingly caffeine and the closely related molecule theophylline blocked this process, providing compelling evidence that caffeine had indeed acted to block the functioning of the p110 delta enzyme.

Speaking today Professor Peter Shepherd, at UCL's Department of Biochemistry and Molecular Biology, said;

" We've shown that caffeine like compounds play a novel role in blocking enzymes known to play a critical role in a range of cellular functions in the body. Along side possible advances in cancer treatment, this research suggests that caffeine type drugs could be used to treat heart disease and inflammatory illnesses."

Professor Shepherd continued;

" But the message to the general public is not to overdose on chocolate or coffee. The study relied on using high concentrations of caffeine that would be unhealthy for human use. Caffeine has well known side effects that make it inappropriate for drug use."

"The next stage of our research will be to develop compounds which mimic the structure of caffeine but without its negative effects."

Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™ FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Safely Burn Away Body Fat Safely Burn Away Body Fat

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map