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The Effects of Sleep Deprivation on Pain Inhibition and Spontaneous Pain in Women

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By MT Smith, et al. • www.ProHealth.com • April 25, 2007


[Note: Spontaneous pain is "pain without an evident stimulus."]

Journal: Sleep. 2007. Vol. 30, Issue 04, pp. 494-505.

Smith MT, Edwards RR, McCann, UD, Haythornthwaite JA. Behavioral Sleep Medicine Program, Johns Hopkins Bayview; Sleep Psychophysiology Laboratory and Behavioral Medicine Research Laboratory; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Impaired central pain modulation is implicated in the pathophysiology of chronic pain. In this controlled experiment, we evaluated whether partial sleep loss altered endogenous pain inhibition and reports of spontaneous pain.

Thirty-two healthy females were studied polysomnographically for 7 nights. On Nights 1-2 (Baseline), subjects slept undisturbed for 8 hours. After Night 2, subjects were randomized to Control (N = 12), Forced Awakening (FA, N = 10), or Restricted Sleep Opportunity (RSO, N = 10) conditions. Controls continued to sleep undisturbed.

FA underwent 8 forced awakenings (one per hour) on Nights 3-5. RSO subjects were yoked to FA on total sleep time (TST), receiving partial sleep deprivation by delayed bedtime. On Night 6, both FA & RSO underwent 36 hours total sleep deprivation (TSD), followed by 11-hour recovery sleep (Night 7).

Subjects completed twice-daily psychophysical assessments of mechanical pain thresholds and pain inhibition (Diffuse Noxious Inhibitory Controls), via use of a conditioning stimulus (i.e., cold pressor) paradigm. [The cold-pressor test involves observing blood pressure response to cold pain associated with immersing one hand in icy water for one minute.]

n Forced Awakening and Restricted Sleep Opportunity demonstrated 50% reductions in total sleep time and increases in nonpainful somatic symptoms during partial sleep deprivation.

n While sleep deprivation had no effect on pain thresholds, during partial sleep deprivation the Forced Awakening group demonstrated a significant loss of pain inhibition and an increase in spontaneous pain;

n Neither of the other 2 groups [the control and restricted sleep opportunity groups] showed changes in pain inhibition or spontaneous pain during partial sleep deprivation.

These data suggest that sleep continuity disturbance, but not simple sleep restriction, impairs endogenous pain-inhibitory function and increases spontaneous pain, supporting a possible pathophysiologic role of sleep disturbance in chronic pain.





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