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EULAR evidence based recommendations for the management of Fibromyalgia syndrome

  [ 295 votes ]   [ 2 Comments ]
By SF Carville, et al. • • August 4, 2007

[Note: EULAR stands for the 11-country European League Against Rheumatism. To read a brief synopsis of the nine EULAR recommendations, click here.]


Objective: To develop evidence based recommendations for the management of Fibromyalgia syndrome (FMS).

Methods: A multidisciplinary task force was formed representing eleven European Countries. The design of the study including search strategy, participants, interventions, outcome measures, data collection and analytical method was defined at the outset. A systematic review was undertaken with the keywords 'fibromyalgia', 'treatment or management' and 'trial'. Studies were excluded if they did not utilize the ACR classification criteria, were not clinical trials, or included patients with Chronic Fatigue Syndrome or myalgic encephalomyelitis.

Primary outcome measures were:


Change in pain assessed by visual analogue scale (VAS) and


Fibromyalgia impact questionnaire (FIQ).

The quality of the studies was categorized based on randomization, blinding and allocation concealment.

Only the highest quality studies were used to base recommendations on. When there was insufficient evidence from the literature, a Delphi process was used to provide basis for recommendation.

Results: One hundred and forty six studies were eligible for the review. Thirty nine pharmacologic intervention studies and 59 non-pharmacologic were included in the final recommendation summary tables once those of a lower quality or with insufficient data were separated.

The categories of treatment identified were antidepressants, analgesics, and 'other pharmacological' and exercise, cognitive behavioral therapy, education, dietary interventions and 'other non-pharmacological'. In many studies sample size was small and the quality of the study was insufficient for strong recommendations to be made.

Conclusion: Nine recommendations for the management of FMS were developed using a systematic review and expert consensus.

Source: Annals of the Rheumatic Diseases. 2007 Jul 20; [E-publication ahead of print] PMID: 17644548, by Carville SF, Arendt-Nielsen S, Bliddal H, Blotman F, Branco JC, Buskilla D, Da Silva JA, Danneskiold-Samsøe B, Dincer F, Henriksson C, Henriksson K, Kosek K, Longley K, McCarthy GM, Perrot S, Puszczewicz MJ, Sarzi-Puttini P, Silman A, Späth M, Choy EH. King's College London, United Kingdom (and 17 other centers). [E-mail: ]

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Article Comments Post a Comment

recommendations for management
Posted by: JONSsis
Aug 8, 2007
Good idea to have the study - bad idea to show no conclusions or further evidence. What does this article achieve?
Reply Reply

So what are the 9 reccommendations???
Posted by: sherrillynn
Aug 8, 2007
Reply Reply
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