ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Curcumin: The All In One Solution, Part 2

CoQ10 — A Nutritional Powerhouse for Mitochondrial Health

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Use Burdock Oil to Promote Healthy Hair Growth

Why You Should Take Your Apple Cider Vinegar at Night

AMA journal associates iron deficiency with hearing loss

Lutein linked to preservation of crystallized intelligence

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

Zinc eaten at levels found in biofortified crops reduces 'wear and tear' on DNA

 
Print Page
Email Article

Fibromyalgia Syndrome's New Paradigm: Neural Sensitization and Its Implications for Treatment

  [ 270 votes ]   [ 3 Comments ]
By Richard N. Podell, MD • www.ProHealth.com • August 16, 2007


Objectives: To provide Fibromyalgia syndrome [FMS] specialists with an overview of information suitable for the education of primary care physicians about current understanding of the mechanism of and treatments for FMS.

Findings: Controlled studies using functional magnetic resonance imaging and other objective markers document FMS as a disorder of increased sensitivity of the central nervous system's pain signaling pathways. This "neural sensitization" model shifts the focus for treatment toward drugs that affect neural pathways.

New options include:

  • 5-hydroxytryptamine serotonin receptor antagonists such as odansetron [Zofran],
  • N-methyl-D-aspartate receptor antagonists such as Ketamine,
  • Growth hormone stimulants such as pyridostigmine [Mestinon],
  • Anti-seizure drugs such as gapapentin [Neurontin] or pregabalin [Lyrica],
  • Gamma hydroxy butyrate-related agonists such as sodium sodium oxybate [Xyrem],
  • And the new serotonin-norepinephrine reuptake inhibitors-class antidepressants such as duloxetine [Cymbalta] and milnacipran.

Also recommended is appropriately graded exercise, i.e., conditioning, work on sleep quality, and cognitive behavioral therapy to support coping skills.

Conclusion: Improved understanding of the neural mechanisms involved in FMS and new options for treatment make it imperative that FMS specialists reach out to educate their primary care physician colleagues.

Source: Journal of Musculoskeletal Pain, Volume: 15 Issue: 2, Page Range: 45 – 54 , DOI: 10.1300/J094v15n02_08, by Podell RN. UMDNJ-Robert Wood Johnson Medical School.





Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg FibroSleep™ Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

New Paradigm
Posted by: bearcat
Aug 22, 2007
Finally we are getting some substantive research that demonstrates the true source of our pain! Although not delineating the etiology it nevertheless serves to validate our pain. I am on three of the newly advised medications (gabapentin,xyrem and cymbalta) and although not cured am so very much better. I am increasingly hopeful as I see research move away from female hysteria approaches to looking at what's going on in our neural systems and brains.
Reply Reply

 
Glad to hear your
Posted by: angelstapleton
Sep 8, 2007
I was glad to hear your doing good. I been sick for about 2 years and have just started to see new Dr. I am hoping to find one that will get me on the right track to aleast feeling better 50% of the time. I live in Mount vernon Mo . So if you know of any please let me know. Thanks Bless you you for your info . Angel

 


Cymbalta
Posted by: applepansy
May 30, 2009
what side effects are you dealing with? thanks
Reply Reply
 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera
Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map