ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Gut Bacteria, Artificial Sweeteners and Glucose Intolerance

Reverse Mitochondrial Damage

Culprits of Autism Identified: Toxins, Gut Bacteria, Nutritional Deficiencies, and Vaccines Made wit...

Turmeric compound boosts regeneration of brain stem cells

CoQ10: The Longevity Factor

Magnesium: Widespread Deficiency with Deadly Consequences

Use of Broad-Spectrum Antibiotics Before Age 2 Associated with Obesity Risk

Is Homocysteine Making You Sick?

Extending Life and Fighting Disease with Resveratrol

VIDEO: Beautiful Clouds - Relaxation and Meditation

 
Print Page
Email Article

Columbia University Medical Center Researchers Lead Placebo-Controlled Study of Cognitive Impairment Among Patients With Previously Treated Lyme Disease

  [ 143 votes ]   [ Discuss This Article ]
By Columbia University Medical Center • www.ProHealth.com • October 26, 2007


NEW YORK, Released Oct 10, 2007 – Researchers at Columbia University Medical Center have added to the body of literature on Lyme disease with the publication of a study entitled, “A Randomized, Placebo-Controlled Trial of Repeated IV Antibiotic Therapy for Lyme Encephalopathy,” in the October 10 online edition of Neurology.

The study, led by principal investigator Brian Fallon, MD, MPH, director of the recently established Lyme and Tick-borne Disease Research Center at Columbia University Medical Center, involved screening 3,368 patients for potential inclusion. Strict selection criteria included memory impairment and a positive IgG Western blot for Lyme disease at study entry, as well as previous antibiotic treatment for Lyme disease completed at least 4 months before study entry. The research was funded by the National Institute of Neurological Disorders and Stroke (NINDS).

Dr. Fallon and his research team identified patients with cognitive problems that developed after diagnosis with Lyme disease and that persisted or relapsed despite prior treatment.

n The goal was to determine whether patients who have already received the “standard” course of antibiotic treatment (three weeks of IV antibiotic therapy), would benefit from an additional 10 weeks of antibiotic therapy.

n They also set out to determine whether patients would relapse when taken off antibiotics or whether the alleviation of symptoms is sustained or enhanced with time.

After elimination of potential study subjects who did not meet inclusion criteria, only 57 study participants remained (37 patients with a history of Lyme disease and 20 healthy controls). They were divided into three subject groups:

n Patients with a history of treated Lyme disease were randomized to IV treatment with an antibiotic called ceftriaxone for 10 weeks;

n Patients with a history of treated Lyme disease were randomized to IV placebo for 10 weeks; and

n Healthy controls were tested at the same time points as the patients to help to control for the practice effect on neuropsychological testing.

“We set out in this study to learn if a repeated course of antibiotics relieves certain symptoms associated with post-treatment chronic Lyme encephalopathy and to assess whether such symptom relief is sustained after patients are taken off antibiotics,” said Dr. Fallon. “The sample group of 23 patients who received 10 weeks of IV ceftriaxone therapy initially showed moderate improvements in cognition when evaluated at the primary outcome assessment point of 12 weeks; however, the improvement in cognition was not sustained in the 6 month (24 week) assessment.”

According to the paper, patients with greater severity of pain, fatigue or physical dysfunction at the start of the study who were randomized to ceftriaxone treatment reported improvement in these symptoms at week 12, as compared to those patients who were given IV placebo.

For a subset of patients who received IV ceftriaxone who started the study with higher levels of pain or physical functioning impairments, the improvement in pain and physical functioning was sustained to week 24. Whether reported improvement was due to a direct antimicrobial effect of the antibiotic or effects on neurotransmitters is unclear. Of concern in this study is that IV ceftriaxone treatment was associated with serious side effects in about one-quarter of the patients.

The paper concludes, “...considering both the limited duration of cognitive improvement and the risks, 10 weeks of IV ceftriaxone and then 14 weeks of no antibiotic is not an effective strategy for sustained cognitive improvement.”....

Patient Queries: To schedule a research evaluation for possible participation in a research study, please call the Lyme and Tick-borne Disease Research Center at 212-543-6510. [Note: Dr. Fallon’s team is currently recruiting for a study titled “SPECT Imaging of Chronic Lyme Disease vs. Other Disorders”]



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health

Natural Remedies

Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
How I Found My Long-Lost Energy How I Found My Long-Lost Energy
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Shoo Pain, Don't Bother Me - Top 10 Nutrients to Take Back Your Life Shoo Pain, Don't Bother Me - Top 10 Nutrients to Take Back Your Life

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing