Patients with Chronic Fatigue Syndrome (CFS) have a broad and variable spectrum of signs and symptoms with variable onsets. This report outlines the results of a single-blind, cross-sectional research project that extensively investigated a large cohort of 100 CFS patients and 82 non fatigued control subjects with the aim of performing a case-control evaluation of alterations in standard blood parameters and urinary amino and organic acid excretion profiles.
Blood biochemistry and full blood counts were unremarkable and fell within normal laboratory ranges.
However, the case-control comparison of the blood cell data revealed that CFS patients had a significant decrease in red cell distribution width [a measure of the variability of red blood cell size] and increases in mean platelet volume, neutrophil counts, and the neutrophil-lymphocyte ratio.
Evaluation of the urine excretion parameters also revealed a number of anomalies. The overnight urine output and rate of amino acid excretion were both reduced in the CFS group (P < 0.01). Significant decreases in the urinary excretion of asparagine (P < 0.0001), phenylalanine (P < 0.003), the branch chain amino acids (P < 0.005), and succinic acid (P < 0.0001), as well as increases in 3-methylhistidine (P < 0.05) and tyrosine (P < 0.05) were observed.
It was concluded that the urinary excretion and blood parameters data supported the hypothesis that alterations in physiologic homeostasis exist in CFS patients.
[Physiologic homeostasis has been defined as regulation of the body’s “internal environment so as to maintain a stable, constant condition.”]
Source: Experimental Biology and Medicine (Maywood). 2007 Sep;232(8):1041-9. PMID: 17720950, by Niblett SH, King KE, Dunstan RH, Clifton-Bligh P, Hoskin LA, Roberts TK, Fulcher GR, McGregor NR, Dunsmore JC, Butt HL, Klineberg I, Rothkirch TB. Environmental and Pathogenic Microbiology Laboratory, School of Environmental and Life Sciences, The University of Newcastle, Callaghan, New South Wales, Australia.