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Fibromyalgia Pain Caused by Neuron Mismatch, UK Researchers Suggest

  [ 150 votes ]   [ 3 Comments ]
By University of Bath, UK • • October 31, 2007

BATH, England, Oct. 31, 2007 - The unexplained pain experienced by patients with Fibromyalgia is the result of a mismatch between sensory and motor systems, new research suggests.

In a study published in the journal Rheumatology*, researchers asked patients to look at a reflection of one arm whilst moving their other in a different direction which was hidden behind the mirror. This created a mismatch between what the brain sees via sensory input and what it feels through the motor system that controls movement.

Of the 29 patients involved in the study, 26 reported feeling a transient increase in pain, temperature change or heaviness in their hidden limb - all symptoms of a ‘flare up’ of their condition. This suggests that a mismatch between sensory and motor neurons could be at the root of the Fibromyalgia – a condition affecting one in 100 people in the UK at some stage of their lives.

“The chronic pain experienced by people with Fibromyalgia is hard to understand because there are no obvious clinical signs that pain should be experienced,” said Dr. Candy McCabe, one of the researchers involved in the University of Bath and Royal National Hospital for Rheumatic Diseases study. “We have shown that by confusing the motor and sensory systems we can exacerbate the symptoms felt by people diagnosed with the condition. This adds to a growing body of evidence that many of the symptoms of this common disorder may be perpetuated, or even triggered, by this sensory-motor conflict.

“We have had some success to date in using a similar technique to help alleviate the symptoms of this kind of chronic pain. This works by helping the brain to see a limb moving freely without pain – although in reality it is a reflection of their pain-free limb.”

Volunteers in the study were asked to perform a series of bilateral upper and lower limb movements with a mirror in front of them at a right-angle. This meant that one limb was obscured from view behind the mirror whilst they could clearly see the other limb and its reflection. They first carried out the same movements with both limbs, and then made different movements. This enabled the researchers to see [the effect of] confusing what the brain could see with what it could feel.

“Nearly all of the group reported an increase in the sensations connected with their condition in the hidden limb,” said Dr. McCabe, who works in the University's School for Health. “This provides strong evidence that sensory-motor conflict is at the heart of this condition. Some clinicians do not recognize Fibromyalgia as a diagnosis because of a lack of clinical reason for the pain.

“It is often considered to be a reflection of anxiety or attention seeking behavior which, for people with the condition, can be very hard to deal with. Nevertheless, Fibromyalgia is one of the most common conditions seen by rheumatologists. Hopefully we are beginning to understand more about the condition, and taking steps toward how it might be treated in the future.”

People with Fibromyalgia complain of widespread pain, multiple tender points, stiffness, sleep disturbance and fatigue. Around nine out of ten of those affected by Fibromyalgia are women. In most cases it develops between the ages of 30 and 60, but it can develop in people of any age, including children and the elderly. There are around 14,700 new cases in the UK each year.

Note: The Royal National Hospital for Rheumatic Diseases NHS Foundation Trust…[home of a Specialist CFS/ME Service for Children and Young Adults] is a national specialist rehabilitation and rheumatology hospital based in Bath. Offering services to adults, children and young people, the trust has expertise general and complex: rheumatological and musculoskeletal conditions, neurological rehabilitation, pain management, management programs for people who suffer from chronic pain and Chronic Fatigue Syndrome / ME.

* This press release refers to the article “Somaesthetic disturbances in Fibromyalgia are exaggerated by sensory-motor conflict: Implications for chronicity of the disease,” published in the October issue of the journal Rheumatology. You can find a summary abstract of the article at and the full text is available free at

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Article Comments Post a Comment

Which Came First?
Posted by: miastella
Nov 7, 2007
This study borders on the ridiculous if those of us with Fibromyalgia are being asked to believe that we are this sick because we lack eye-hand coordination. However, given that Fibro is very likely damage to the nervous system, this study may indicate another symptom created by Primary Fibromyalgia. Researchers have not always been as circumspect about their outcomes as they ought to be, which can waste time and expend energy we can't afford to lose.
Reply Reply

Posted by: Svette_Palme
Apr 22, 2008
I can understand your skepticism, but I think that they are just saying that test was a way to show that the our [chronic pain] brain is not working right. It is not saying that hand-eye coordination is at the root of our problem, but just that it is one symptom.

The neuron mismatch theory will give us credibility - our pain is real, it is serious, and we deserve all the help we can get.


original thinking
Posted by: 545
Nov 7, 2007
I agree with Miastella that all researchers could use a healthy added dose of skepticism. However, I do have to say that this is one of the more original studies I've seen in a long time. It was particularly interesting that the symptoms they provoked corresponded to those indicative of a flare-up. This might suggest that we're finally getting at some sort of root cause, rather than just studying intermediary/secondary symptoms. It's interesting too think how this mix-up might be played out on a larger scale. This was a specific and controlled study, but what are the implications? If a body can't discern pain from one limb with pain in another, would it have normal digestion? Sensory perception? Immune functioning? And on a larger level, if this sort of mix-up can cause a real flare, then perhaps we can learn how to stick a wrench in this process - biologically speaking.
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