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Gender Differences Among Patients with Fibromyalgia Undergoing Multidisciplinary Pain Rehabilitation - Source: Pain Medicine, Nov-Dec 2007

  [ 15 votes ]   [ Discuss This Article ]
By W. Michael Hooten, ME, et al. • • November 17, 2007

Objective: This study was conducted to test the hypothesis that gender differences in physical and emotional functioning are present among patients with fibromyalgia undergoing multidisciplinary pain rehabilitation.

Design: Retrospective case-matched series.

Setting: Multidisciplinary pain rehabilitation center at a tertiary referral medical center.

Patients: Thirty-three consecutive men with Fibromyalgia admitted from January 2002 through June 2005 were matched to 33 women with Fibromyalgia for age, treatment dates, and program completion status.

Interventions: A 3-week outpatient multidisciplinary pain rehabilitation program based on a cognitive-behavioral model that incorporates analgesic medication withdrawal.

Outcome Measures: Multidimensional Pain Inventory (MPI), Short Form-36 Health Status Questionnaire (SF-36), Coping Strategies Questionnaire-Catastrophizing subscale (CSQ-C), and the Center for Epidemiologic Studies-Depression scale (CES-D) were administered before and after treatment. The numbers of patients using opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), and benzodiazepines before and after treatment were compared.


  • Pretreatment MPI and SF-36 scores revealed men had lower health perception (P = 0.017) and more physical limitations (P = 0.004)
  • While women had greater life interference due to pain (P = 0.005).
  • Mean differences in all pre- and post-treatment outcome measures demonstrated a statistically significant treatment response.
  • However, men had lower post-treatment scores on the SF-36 health perception (P = 0.023), role limitations-physical (P = 0.021), and social functioning (P = 0.033) subscales.
  • Significant within-gender reductions in opioid analgesic, NSAID, and benzodiazepine use were observed but no significant between-gender differences were identified.
  • Conclusions:These results support the hypothesis that pretreatment gender differences are present among Fibromyalgia patients undergoing multidisciplinary pain rehabilitation, and post-treatment gender differences persist despite improvements in physical and emotional functioning.

    Source: Pain Medicine. Nov-Dec 2007, vol 8 #8, pp 624-632. DOI:10.1111/j.1526-4637.2006.00202.x by Hooten WM, Townsend, CO, Decker PA. Departments of Anesthesiology and Psychiatry and Psychology, Division of Biostatistics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA [E-mail:]

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