ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Natural Bladder Control, Go Less and Live More

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Top Vitamin and Mineral Deficiencies — Are You at Risk?

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

Trimming the spare tire: Canola oil may cut belly fat

The Onion: Cancer Fighter and Food Preserver

Fighting Heartburn and Gerd Naturally – And Safely!

Probiotics improve cognition in Alzheimer's patients

 
Print Page
Email Article

Extra Digestive Manifestations of Irritable Bowel Syndrome: Intolerance to Drugs? - Source: Digestive Diseases and Sciences, Dec 20, 2007

  [ 130 votes ]   [ Discuss This Article ]
By Pierre Poitras, et al. • www.ProHealth.com • December 29, 2007


Patients with Irritable Bowel Syndrome (IBS) frequently complain of medication side effects. The goals of this study were to assess the prevalence of drug intolerance as an extra gastrointestinal (GI) manifestation in patients with IBS and to verify the association between drug intolerance and psychological comorbidity.

Female patients followed in a tertiary care center completed questionnaires assessing the presence of drug intolerance as well as somatic and psychological extra GI conditions. IBS patients (Rome II criteria; n = 71) were compared to inflammatory bowel disease patients (IBD; n = 96) or to healthy controls (HC; n = 67).

The relationship to psychological comorbidity was verified in two different paradigms:
(1) By looking at the statistical correlation between drug intolerance and the psychological extra GI symptoms in our IBS patients, and
(2) By comparing in a meta-analysis the side effects to placebo (the nocebo effect is presumably increased due to hypervigilance or amplification in psychological disorders) in IBS patients or in patients with comparable medical conditions included in various drug trials approved by Health Canada. [Note: "Nocebo” refers to a negative response to a fake or dummy drug dose.]

Our results show that:

  • Prevalence of drug intolerance was significantly more elevated in IBS (41% patients) than in HC (7%) or in IBD (27%);
  • Somatic and psychological extra GI symptoms were also markedly increased in IBS.
  • In addition, drug intolerance in our IBS patients was significantly associated with somatic comorbidities such as fatigue or multiple symptoms (P < 0.001), but not with psychological factors such as depression, anxiety, mood instability, or sleep disorder.
  • A meta-analysis revealed that the nocebo effect was not different in patients with IBS than in control patients.
  • In conclusion, drug intolerance is a frequent extra GI manifestation of IBS that is not associated with psychological comorbidity; thus, a somatic origin must be explored.

    Source: Digestive Diseases and Sciences. Dec 20, 2007 Dec 20 [E-pub ahead of print] PMID: 18095162, by Poitras P, Gougeon A, Binn M, Bouin M. Centre de recherche, Centre hospitalier de l’Universite de Montreal—Hopital Saint-Luc, Montreal, Quebec, Canada. [E-mail: pierre.poitras@sympatico.ca





    Post a Comment

    Featured Products From the ProHealth Store
    Vitamin D3 Extreme™ FibroSleep™ Mitochondria Ignite™ with NT Factor®


    Article Comments



    Be the first to comment on this article!

    Post a Comment


     
    Natural Pain Relief Supplements

    Featured Products

    Energy NADH™ 12.5mg Energy NADH™ 12.5mg
    Improve Energy & Cognitive Function
    Vitamin D3 Extreme™ Vitamin D3 Extreme™
    50,000 IU Vitamin D3 - Prescription Strength
    Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
    Reduce Fatigue up to 45%
    Ultra ATP+, Double Strength Ultra ATP+, Double Strength
    Get energized with malic acid & magnesium
    Optimized Curcumin Longvida® Optimized Curcumin Longvida®
    Supports Cognition, Memory & Overall Health

    Natural Remedies

    Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?
    Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
    The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream
    When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...
    Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health

    CONTACT US
    ProHealth, Inc.
    555 Maple Ave
    Carpinteria, CA 93013
    (800) 366-6056  |  Email

    · Become a Wholesaler
    · Vendor Inquiries
    · Affiliate Program
    SHOP WITH CONFIDENCE
    Credit Card Processing
    SUBSCRIBE TO OUR NEWSLETTERS
    Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

    CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

    © 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map