ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is a Good Night's Sleep at the Top of Your Wishlist?

Ashwagandha Helps Hormones - Aids Arthritis

Why You Should Be Eating More Porcini Mushrooms

A Breathalyzer for Disease?

How Bacopa Can Help Improve Your Cognitive Function

Magnesium Reduces Diabetes and Helps Keep You Young

Lavender Aromatherapy Can Ease Pre-Op Anxiety

Give Your Health a Much-Needed Boost With Geranium

The Role of Resveratrol in Achieving Optimal Health

Could Coconut Oil Help Reduce Antibiotics?

 
Print Page
Email Article

Extra Digestive Manifestations of Irritable Bowel Syndrome: Intolerance to Drugs? - Source: Digestive Diseases and Sciences, Dec 20, 2007

  [ 130 votes ]   [ Discuss This Article ]
By Pierre Poitras, et al. • www.ProHealth.com • December 29, 2007


Patients with Irritable Bowel Syndrome (IBS) frequently complain of medication side effects. The goals of this study were to assess the prevalence of drug intolerance as an extra gastrointestinal (GI) manifestation in patients with IBS and to verify the association between drug intolerance and psychological comorbidity.

Female patients followed in a tertiary care center completed questionnaires assessing the presence of drug intolerance as well as somatic and psychological extra GI conditions. IBS patients (Rome II criteria; n = 71) were compared to inflammatory bowel disease patients (IBD; n = 96) or to healthy controls (HC; n = 67).

The relationship to psychological comorbidity was verified in two different paradigms:
(1) By looking at the statistical correlation between drug intolerance and the psychological extra GI symptoms in our IBS patients, and
(2) By comparing in a meta-analysis the side effects to placebo (the nocebo effect is presumably increased due to hypervigilance or amplification in psychological disorders) in IBS patients or in patients with comparable medical conditions included in various drug trials approved by Health Canada. [Note: "Nocebo” refers to a negative response to a fake or dummy drug dose.]

Our results show that:

  • Prevalence of drug intolerance was significantly more elevated in IBS (41% patients) than in HC (7%) or in IBD (27%);
  • Somatic and psychological extra GI symptoms were also markedly increased in IBS.
  • In addition, drug intolerance in our IBS patients was significantly associated with somatic comorbidities such as fatigue or multiple symptoms (P < 0.001), but not with psychological factors such as depression, anxiety, mood instability, or sleep disorder.
  • A meta-analysis revealed that the nocebo effect was not different in patients with IBS than in control patients.
  • In conclusion, drug intolerance is a frequent extra GI manifestation of IBS that is not associated with psychological comorbidity; thus, a somatic origin must be explored.

    Source: Digestive Diseases and Sciences. Dec 20, 2007 Dec 20 [E-pub ahead of print] PMID: 18095162, by Poitras P, Gougeon A, Binn M, Bouin M. Centre de recherche, Centre hospitalier de l’Universite de Montreal—Hopital Saint-Luc, Montreal, Quebec, Canada. [E-mail: pierre.poitras@sympatico.ca





    Post a Comment

    Featured Products From the ProHealth Store
    Ultra ATP+, Double Strength Optimized Curcumin Longvida® Vitamin D3 Extreme™


    Article Comments



    Be the first to comment on this article!

    Post a Comment


     
    Optimized Curcumin Longvida with Omega-3

    Featured Products

    Ultra ATP+, Double Strength Ultra ATP+, Double Strength
    Get energized with malic acid & magnesium
    Optimized Curcumin Longvida® Optimized Curcumin Longvida®
    Supports Cognition, Memory & Overall Health
    FibroSleep™ FibroSleep™
    The All-in-One Natural Sleep Aid
    Vitamin D3 Extreme™ Vitamin D3 Extreme™
    50,000 IU Vitamin D3 - Prescription Strength
    Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
    Reduce Fatigue up to 45%

    Natural Remedies

    Top 3 Nutrients to Detox the Liver and Soothe Digestion Top 3 Nutrients to Detox the Liver and Soothe Digestion
    Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold
    The Super Antioxidant for Brain, Joint and Heart Health The Super Antioxidant for Brain, Joint and Heart Health
    Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones
    Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine

    CONTACT US
    ProHealth, Inc.
    555 Maple Ave
    Carpinteria, CA 93013
    (800) 366-6056  |  Email

    · Become a Wholesaler
    · Vendor Inquiries
    · Affiliate Program
    SHOP WITH CONFIDENCE
    Credit Card Processing
    SUBSCRIBE TO OUR NEWSLETTERS
    Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

    CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

    © 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map