ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimm...

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Acupressure reduced fatigue in breast cancer survivors

Omega-3 fatty acid stops known trigger of lupus

What’s Fenugreek Good For?

Print Page
Email Article

UT Southwestern scientist explores caffeine-signaling activity in brain function

  [ 72 votes ]   [ Discuss This Article ] • August 29, 2002

DALLAS – Aug. 29, 2002 – Every morning millions of Americans reach for the world's most popular drug to help them start their day.

"That drug is caffeine," said Dr. James Bibb, assistant professor of psychiatry at UT Southwestern Medical Center at Dallas. Bibb is one of the authors of a new report explaining how caffeine exerts its stimulatory effect by altering the biochemistry of the brain. The findings appear in an August issue of Nature.

"Caffeine is the most frequently self-administered drug in recreational use worldwide today," Bibb said. "And yet we know little about how caffeine works in the brain, whether with the kick from a double espresso or small jolts from tea or cola. We do know it is rewarding, can enhance cognition and performance, and induce dependence at the same time."

Bibb said most people would never consider that the effects of their morning coffee would have any similarities to those of cocaine, long known to be a powerful and dangerous recreational drug. But research is showing that the two stimulants similarly alter a specific signaling activity within the brain.

The researchers involved in the Nature paper used genetically altered mice lacking DARPP-32, a protein known to play a role in drug addiction, to explore questions about caffeine's stimulant effects. Normal mice given a 7.5 milligram/kilogram dose of caffeine showed a dramatic increase in long-range (locomotion) and short-range (motility) movements for as long as 100 minutes. This amount of caffeine is the equivalent of about three cups of coffee for a person weighing 160 pounds. When scientists gave the mice lacking DARPP-32 the same dose, it had little effect. Only by doubling the dose to 15 mg/kg were researchers able to overcome the knockout effect of gene deletion.

Bibb said these results were similar to those of his previous studies that explored the same biochemical pathways activated by cocaine.

Bibb explained that it has been known for some time that caffeine owes much of its stimulant action to its ability to block receptors, such as those for adenosine, in the brain. Adenosine, one of the four building blocks of DNA and an important signaling molecule in the brain, forms the backbone of the energy-storage molecule ATP. ATP helps maintain equilibrium, or balance, between its energy use and electrical activity throughout the cells, sending signals along specific brain pathways.

Bibb is a former Rockefeller University scientist who is continuing his research at UT Southwestern on the processes in the brain that control addiction and other neurological and psychiatric disorders. Much of his research involves identifying processes that regulate brain biochemistry and determining how these are triggered by specific drugs of abuse or neuropsychiatric diseases. Some of his early findings on these biochemical pathways and how cocaine affects them have appeared in two earlier reports in Nature.

Bibb said insights into the mechanisms of both cocaine and caffeine on the brain have led him to investigate the processes in the brain that control sleep. He is currently working on new sleep studies with other scientists, including Dr. Robert Greene, vice chairman of psychiatry for VA services at UT Southwestern.

"We find that in the brain many processes are related, and it is well-known that caffeine can induce insomnia and that adenosine can induce sleep. By studying sleep we may also learn more about drug addiction and other disorders," Bibb said.

The caffeine research was conducted by scientists at Rockefeller University in New York City; the Karolinska Institute in Stockholm, Sweden; and the "Mario Negri" Institute for Pharmacological Research in Milan, Italy.

The study was funded by the Swedish Research Council, the National Institute of Mental Health and the National Institute on Drug Abuse.

Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra ATP+, Double Strength Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones
Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients
Help for Soreness and Swelling: What Do Silkworms Have to Do With It? Help for Soreness and Swelling: What Do Silkworms Have to Do With It?
Relief for Dry, Itchy Skin Caused by Fibromyalgia Relief for Dry, Itchy Skin Caused by Fibromyalgia
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map