ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

How Can You Benefit From Vitamin B12?

Discover Why Ashwagandha Can Be Used for Stress and Anxiety

Calorie restriction promotes longevity through effects on mitochondrial network

Higher resveratrol dose linked to lower glucose levels in type 2 diabetics

Tryptophan's Possible Effects for Your Health

What Is Bitter Orange?

Black Tea Is Great for Your Gut

Drug can dramatically reduce weight of people with obesity

Ashwagandha Helps Hormones - Aids Arthritis

New Finding: Broccoli Helps Heal Leaky Gut

 
Print Page
Email Article

A six-month randomized controlled trial of exercise and pyridostigmine in the treatment of Fibromyalgia - Source: Arthritis and Rheumatism, Jan 31, 2008

  [ 17 votes ]   [ Discuss This Article ]
By KD Jones, RM Bennett, et al. • www.ProHealth.com • February 21, 2008


[Note: piridostigmine is a drug that facilitates transmission of nerve impulses across the neuromuscular junction. It is used to treat myasthenia gravis and, recently, postural hypotension.]

Objective: A subset of fibromyalgia (FM) patients have a dysfunctional hypothalamic-pituitary-insulin-like growth factor 1 (IGF-1) axis, as evidenced by low serum levels of IGF-1 and a reduced growth hormone (GH) response to physiologic stimuli. There is evidence that pyridostigmine (PYD) improves the acute response of GH to exercise in FM patients. The purpose of this study was to evaluate the clinical effectiveness of 6 months of PYD and group exercise on FM symptoms.

Methods: FM patients were randomized to 1 of the following 4 groups:

  • PYD plus exercise,
  • PYD plus diet recall but no exercise,
  • Placebo plus exercise, and
  • Placebo plus diet recall but no exercise.

The primary outcome measures were the visual analog scale (VAS) score for pain, tender point count, and total myalgic score. Secondary outcome measures were the total score on the Fibromyalgia Impact Questionnaire (FIQ) and FIQ VAS scores for individual symptoms (fatigue, poor sleep, stiffness, and anxiety), as well as quality of life (QOL) and physical fitness (lower body strength/endurance, upper and lower body flexibility, balance, and time on the treadmill).

Results: A total of 165 FM patients completed baseline measurements; 154 (93.3%) completed the study.

  • The combination of PYD and exercise did not improve pain scores.
  • PYD groups showed a significant improvement in sleep and anxiety in those who completed the study and in QOL in those who complied with the therapeutic regimen as compared with the placebo groups.
  • Compared with the nonexercise groups, the 2 exercise groups demonstrated improvement in fatigue and fitness.
  • PYD was generally well tolerated.

Conclusion:

  • Neither the combination of PYD plus supervised exercise nor either treatment alone yielded improvement in most FM symptoms.
  • However, PYD did improve anxiety and sleep,
  • And exercise improved fatigue and fitness.

We speculate that PYD may have improved vagal tone, thus benefiting sleep and anxiety; this notion warrants further study. [Note: The vagus nerve influences the resting heart beat. When the heart rate varies considerably for each respiratory cycle – elevated when taking a breath, depressed when exhaling – “vagal tone” is good or high. When heart rate is relatively steady through the cycle, vagal tone is poor or low.]

Source: Arthritis and Rheumatism. 2008 Jan 31;58(2):612-622 [Epub ahead of print] PMID: 18240245, by Jones KD, Burckhardt CS, Deodhar AA, Perrin NA, Hanson GC, Bennett RM. Oregon Health & Science University, Portland, Oregon, USA. [E-mail: KD Jones joneskim@ohsu.edu





Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Physically and Mentally Exhausted? How to Restore Energy at Its Source Physically and Mentally Exhausted? How to Restore Energy at Its Source
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
Joint Aches May Have Met Their Match in Curcumin Joint Aches May Have Met Their Match in Curcumin
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map