ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

16 Tips from 16 Years Sick

Fibromyalgia Fare Fit for All Seasons

New Study Shows Artificial Sweeteners Lead to Diabetes

Essential Oils — An Effective and Healthy Option to Treat Headaches

Antioxidant treatment could halt neurodegeneration in early Parkinson's

Higher vitamin D levels associated with less severe disease in NAFLD patients

Krill Oil: Make This Omega-3 Supplement Part of Your Health Regimen

How zinc helps fight esophageal cancer

Everything You Need to Know About Black Cohosh

Low vitamin D levels predict ED in diabetics

 
Print Page
Email Article

A six-month randomized controlled trial of exercise and pyridostigmine in the treatment of Fibromyalgia - Source: Arthritis and Rheumatism, Jan 31, 2008

  [ 17 votes ]   [ Discuss This Article ]
By KD Jones, RM Bennett, et al. • www.ProHealth.com • February 21, 2008


[Note: piridostigmine is a drug that facilitates transmission of nerve impulses across the neuromuscular junction. It is used to treat myasthenia gravis and, recently, postural hypotension.]

Objective: A subset of fibromyalgia (FM) patients have a dysfunctional hypothalamic-pituitary-insulin-like growth factor 1 (IGF-1) axis, as evidenced by low serum levels of IGF-1 and a reduced growth hormone (GH) response to physiologic stimuli. There is evidence that pyridostigmine (PYD) improves the acute response of GH to exercise in FM patients. The purpose of this study was to evaluate the clinical effectiveness of 6 months of PYD and group exercise on FM symptoms.

Methods: FM patients were randomized to 1 of the following 4 groups:

  • PYD plus exercise,
  • PYD plus diet recall but no exercise,
  • Placebo plus exercise, and
  • Placebo plus diet recall but no exercise.

The primary outcome measures were the visual analog scale (VAS) score for pain, tender point count, and total myalgic score. Secondary outcome measures were the total score on the Fibromyalgia Impact Questionnaire (FIQ) and FIQ VAS scores for individual symptoms (fatigue, poor sleep, stiffness, and anxiety), as well as quality of life (QOL) and physical fitness (lower body strength/endurance, upper and lower body flexibility, balance, and time on the treadmill).

Results: A total of 165 FM patients completed baseline measurements; 154 (93.3%) completed the study.

  • The combination of PYD and exercise did not improve pain scores.
  • PYD groups showed a significant improvement in sleep and anxiety in those who completed the study and in QOL in those who complied with the therapeutic regimen as compared with the placebo groups.
  • Compared with the nonexercise groups, the 2 exercise groups demonstrated improvement in fatigue and fitness.
  • PYD was generally well tolerated.

Conclusion:

  • Neither the combination of PYD plus supervised exercise nor either treatment alone yielded improvement in most FM symptoms.
  • However, PYD did improve anxiety and sleep,
  • And exercise improved fatigue and fitness.

We speculate that PYD may have improved vagal tone, thus benefiting sleep and anxiety; this notion warrants further study. [Note: The vagus nerve influences the resting heart beat. When the heart rate varies considerably for each respiratory cycle – elevated when taking a breath, depressed when exhaling – “vagal tone” is good or high. When heart rate is relatively steady through the cycle, vagal tone is poor or low.]

Source: Arthritis and Rheumatism. 2008 Jan 31;58(2):612-622 [Epub ahead of print] PMID: 18240245, by Jones KD, Burckhardt CS, Deodhar AA, Perrin NA, Hanson GC, Bennett RM. Oregon Health & Science University, Portland, Oregon, USA. [E-mail: KD Jones joneskim@ohsu.edu





Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Energy NADH™ 12.5mg Optimized Curcumin Longvida®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire
How Glutathione Can Save Your Life How Glutathione Can Save Your Life
Live Without Anxiety or Stress Live Without Anxiety or Stress

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map