ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Vitamin D supplementation extends life in mouse model of Huntington's disease

Omega-3 fatty acid stops known trigger of lupus

Conquer Your Email Inbox, Increase Productivity and Reduce Stress

The Significance of Selenium

Print Page
Email Article

Caffeine Said To Lower Cancer Risk

  [ 10 votes ]   [ Discuss This Article ] • August 30, 2002

WASHINGTON (AP) -- Laboratory mice slathered with caffeine developed fewer skin tumors than untreated animals, suggesting the chemical that adds zip to coffee and tea also may protect against skin cancer, researchers say.

Dr. Allan Conney, a professor of cancer and leukemia research at Rutgers University, said a skin lotion spiked with caffeine or with another compound found in green tea reduced by more than half the number of skin tumors on hairless mice that had been exposed to high levels of ultraviolet radiation.

"We had between 50 to 70 percent tumor formation inhibition in the mice that were treated with caffeine or with EGCG (the other chemical compound)," said Conney, senior author of a study appearing this week in the online site of the Proceedings of the National Academy of Sciences.

Skin cancer is the most common of all cancers in the United States. The American Academy of Dermatology estimates about a million cases will be diagnosed in the country this year. Among them will be more than 88,000 new cases of melanoma, the disease's deadliest form. Skin cancer generally is curable by cutting, burning or freezing the tumor cells, but left untreated it can be deadly.

To test the effects of caffeine on skin cancer, Conney and his colleagues exposed 90 mice to high levels of ultraviolet radiation twice a day for 20 days. They used a strain of animals called hairless mice, commonly used for skin cancer studies.

After the mice got their UVB doses, the animals were divided into three groups. One group was anointed daily with a solution of acetone and caffeine. Another group received acetone and EGCG. The third group got skin applications of acetone only. Acetone is an organic solution often used on the skin.

At the end of 18 weeks, the three groups of mice were killed, and the level of skin tumor formation was analyzed.

Conney said mice in all three groups developed malignant skin tumors, called squamous cell carcinomas, but the number of tumors per mouse was reduced by 72 percent in those treated with caffeine and by 66 percent among those treated with EGCG, compared to the controls treated only with acetone.

The treated mice also had fewer nonmalignant, sunlight-related tumors, said Conney. Compared to the control group of mice, the mice treated with caffeine had 44 percent fewer nonmalignant tumors and the EGCG group 55 percent fewer, he said.

Conney said that although both compounds were effective in lowering tumor risk, caffeine has an advantage because it is chemically more stable than EGCG.

Unlike sun screen lotions, which protect against skin cancer by preventing the skin from absorbing ultraviolet rays from the sun, the caffeine's cancer protection works in the cells after exposure to the ultraviolet rays. Rays from the sun can cause genetic changes in the skin that can lead to skin cancer. Conney said caffeine apparently blocks this action by causing abnormal cells to kill themselves, a type of programed cell suicide that prevents the development of abnormal growths.

"This is not a sunscreening effect," said Conney. "It is a biological effect."

He said the caffeine acts selectively, causing the abnormal cells to die but not affecting the normal cells.

Caffeine, heavily consumed in coffee, tea and some cola drinks, has been shown in other studies to prompt mental alertness in many people. Some studies have suggested caffeine aggravates symptoms of menopause or intensifies the side effects of some antibiotics. Heavy caffeine use has been linked to miscarriage. Some studies also have suggested that some people can become addicted to caffeine and can experience headaches and other symptoms when deprived of their morning coffee or cola.

Dr. Darrell Rigel, a professor of dermatology at New York University and an expert spokesman for the American Academy of Dermatology, said research like Conney's is needed badly because skin cancer is a major problem.

"I hope this treatment can prove itself, because there are more skin cancers than all other cancers combined in the U.S.," he said.

He said there is a need for a "morning-after" treatment for skin cancer, a therapy that would reduce cancer risk after excessive sun exposure.

Rigel said that although hairless mice are commonly used for such research, "there is really no good animal model for skin cancer. The hairless mouse is the best of a bunch of bad choices" for testing skin cancer compounds in the laboratory.

As a result, he said, "a lot of things that work in mice cannot be extrapolated to humans."

He said other treatments that showed promise in mice have often failed when tried on humans.

Conney said the next step in studying the topical effects of caffeine will be to use the solution on people who are highly susceptible to skin cancer - people who have a precancerous condition or who already have had skin cancer.

In another study in Proceedings, researchers studying the effects of alpha and gamma radiation on cells found caffeine prevented some genes from being repaired after they were damaged by radiation. The study, by researchers at Eleanor Roosevelt Institute and Los Alamos National Laboratories, used Chinese hamster ovary cells in a laboratory dish for their study.

Copyright 2002 The Associated Press. All rights reserved.

Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor® Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map