ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

16 Tips from 16 Years Sick

Fibromyalgia Fare Fit for All Seasons

New Study Shows Artificial Sweeteners Lead to Diabetes

Essential Oils — An Effective and Healthy Option to Treat Headaches

Antioxidant treatment could halt neurodegeneration in early Parkinson's

Higher vitamin D levels associated with less severe disease in NAFLD patients

Krill Oil: Make This Omega-3 Supplement Part of Your Health Regimen

How zinc helps fight esophageal cancer

Everything You Need to Know About Black Cohosh

Low vitamin D levels predict ED in diabetics

Print Page
Email Article

The relationship between fibromyalgia and major depressive disorder: A comprehensive review – Source: Current Medical Research and Opinion, July 2008

  [ 47 votes ]   [ 2 Comments ]
By Chi-Un Pae, et al. • • July 18, 2008

[Note: This international team’s review of the current science comparing and contrasting FM and MDD is available free online. It includes 144 footnotes, tables laying out biological test results for the two conditions, a listing of depression drug results in FM trials, and much more.]

Objective: A large body of evidence suggests that the relationship between major depressive disorder (MDD) and fibromyalgia (FM) is complex. Improved understanding of this relationship promises to provide clinicians with better assessment and treatment options for both disorders.

Method: This paper reviews research on the prevalence, etiology and pathogenesis, clinical characterization, and treatment of FM and MDD, as well as studies that examined the relationship between these disorders. Studies were identified via PubMed literature search.


  • Our findings point to substantial similarities in neuroendocrine abnormalities, psychological characteristics, physical symptoms and treatments between FM and MDD.
  • However, currently available findings do not support the assumption that MDD and FM refer to the same underlying construct or can be seen as subsidiaries of one disease concept.


  • New methodological and theoretical approaches may lead to a better understanding of the link between FM and MDD, and to more effective psychological and psychopharmacological therapies for FM patients.
  • In the meantime, clinicians should carefully screen for a history of MDD in patients with FM.

Source: Current Medical Research and Opinion, Jul 4, 2008. 24(8) 2359-2371. PMID: 18606054, by Pae CU, Luyten P, Marks DM, Han C, Park SH, Patkar AA, Masand PS, Van Houdenhove B. Catholic University of Korea College of Medicine, Seoul, South Korea; Duke University Medical Center, Durham, North Carolina, USA; University of Leuven and University Hospitals, Leuven, Belgium. [E-mail: Chi-Un Pae]

Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Energy NADH™ 12.5mg FibroSleep™

Article Comments Post a Comment

Relationship between Fibromyalgia and Major depressive disorder
Posted by: judimld
Jul 23, 2008
Before I finally got diagnosed with CFS/FM/MCI I was told that I was depressed, even though I kept insisting I was not depressed and many times it was written on my files "denies being depressed" and "a pleasant lady" When I had a psychotic reaction that lasted a day or so, when I was on Prozac 10mg. and Trinalin for an upper respiratory infection, I was diagnosed with Bipolar disorder, and from there I spent three years in a psychiatric trap, taking psychotropic medications that reduced me to a very sick person, losing all muscular strength, moderate to severe memory loss, and abnormal eegs, not to mention thyroid shutdown and the inability to be gainfully employed, due to severe fatigue. For the first time in my life at fifty years of age, I was debilitated,not to mention 6 hospital admissions, mainly due to drug reactions and emotional stress that were diagnosed as psychiatric episodes from Bipolar Disorder. This also was diagnosed as the depressive stage of Bipolar Disorder, and I was not taken seriously until I nearly died with congestive heart failure. By this time I was having so much difficulty breathing, I could not lie flat or have any blankets on me. My ankles were swollen to my knees as I was highly sensitive to lithium, but nobody would believe me and attributed all my symptoms to depression. It has been ten years now since I was diagnosed with FM/CFS/MCI. I have had not one bout of depression, nor mania, but still carry the moniker of mental illness, which I cannot escape from. I have had no connection with psychiatry for eight years, even though it was a stipulation for me to attend a psychiatrist to collect diagbility payments. I challenged that and have not lost my benefits. I have a wonderful female general practitioner who refers me to specialists when the need arises. The only medication I take is Synthroid. I pace myself, live a very healthy lifestyle and have regained my muscular strength to the point that I am back where I was in 1995, but thirteen years older coping with the symptoms of CFS/FM/MCI. I am the director for the Atlantic provinces for the ME/FM Action Network and would like to have this story told. There is a difference between major Depresssive illness, Bipolar disorder and FM/CFS/MCI. When a person states they do not feel sad, not suicidal, not negative, not moody, knows when they are feeling "strange" while taking drugs that are known to cause psychosis, they should be believed and their symptoms investigated further. it would have saved me a great deal of grief over the past thirteen years. Judith Day Atlantic and Territories Director ME/FM Action Network
Reply Reply

judith day's horror story
Posted by: justplainsandi
Aug 20, 2008
judith, you have both my sympathy and my congratulations. you were in a trap that was not of your making and you not only got yourself out, you're using the experience wisely and well.

i had my own version of this story way back in the 60s. i was legitimately sad. i was also at what dr. pellegrino might call the prodromal stage of fibromyalgia. my doctor didn't think i should be sad and started giving me psychoactive drugs. i think that these drugs pushed me into the next stages of fibromyalgia.

my body doesn't handle drugs, any drugs, well. whenever i complained about how they made me feel, which were known side effects, he added another drug, which made me feel even worse. but i was trusting and obedient and took my medicine.

long story short, eventually i broke completely and was court committed for psychiatric observation. the doctors didn't know what to do with me until one decided to experiment with taking me off all of the medication. that was when i started getting better. i later learned that i am allergic to a whole class of the drugs i was given.

i've been very cautious about doctors and drugs ever since, even though every once in a while i still have to "pay my dues" to get past a credibility gap and into a program i need. so far i've been right and the doctor wrong every time. also so far, only 2 doctors have gone far enough to help me find something that will work.

good luck with your action network. i will share your story.



Optimized Curcumin Longvida with Omega-3

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Eating Fat is Good... Maybe... Could Be... Sometimes Eating Fat is Good... Maybe... Could Be... Sometimes
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
How Glutathione Can Save Your Life How Glutathione Can Save Your Life
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map