[Note: human and primate studies have indicated that the lateral prefrontal cortex is “critically involved in broad aspects of executive behavioral control.” Specifically, in selective attention, behavioral planning, and selecting an intended action
Chronic fatigue syndrome (CFS) is a disabling disorder, characterized by persistent or relapsing fatigue.
Recent studies have detected a decrease in cortical grey matter volume in patients with CFS, but it is unclear whether this cerebral atrophy constitutes a cause or a consequence of the disease.
Cognitive behavioral therapy (CBT) is an effective behavioral intervention for CFS, which combines a rehabilitative approach of a graded increase in physical activity with a psychological approach that addresses thoughts and beliefs about CFS which may impair recovery.
Here, we test the hypothesis that cerebral atrophy may be a reversible state that can ameliorate with successful CBT. We have quantified cerebral structural changes in 22 CFS patients that underwent CBT and 22 healthy control participants.
At baseline, CFS patients had significantly lower grey matter volume than healthy control participants.
CBT intervention led to a significant improvement in health status, physical activity and cognitive performance.
Crucially, CFS patients showed a significant increase in grey matter volume, localized in the lateral prefrontal cortex.
This change in cerebral volume was related to improvements in cognitive speed in the CFS patients.
Our findings indicate that the cerebral atrophy associated with CFS is partially reversed after effective CBT.
This result provides an example of macroscopic cortical plasticity in the adult human brain,
Demonstrating a surprisingly dynamic relation between behavioral state and cerebral anatomy.
Furthermore, our results reveal a possible neurobiological substrate of psychotherapeutic treatment.
Source: Brain, June 28, 2008. PMID: 18587150, by de Lange FP, Koers A, Kalkman JS, Bleijenberg G, Hagoort P, van de Meer JWM, Toni I. Donders Centre for Cognitive Neuroimaging and Nijmegen Institute for Cognition and Information, Radboud University Nijmegen; Expert Center Chronic Fatigue and Department of General Internal Medicine, Radboud University Nijmegen Medical Center, Netherlands. [E-mail: email@example.com]