ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Coconut Oil Healthy? (The American Heart Association Doesn’t Think So)

American Heart Association Renders Itself Obsolete With 1960s Dietary Advice on Coconut Oil

Ginger Fights Obesity

Health Benefits of Artichokes

Putting the Spotlight on Coriander Seed Oil

Migraines? Powdered Ginger May Help

Are Americans Really Getting Too Much Vitamin D? A Critical Look at Recent Media Warnings

Eating more vegetable protein may protect against early menopause

German Chamomile Oil: A Versatile Essential Oil You Should Have at Home

Vitamin C and antibiotics: A new one-two 'punch' for knocking-out cancer stem cells

Print Page
Email Article

Inflammation in the uterus induces phosphorylated extracellular signal-regulated kinase and substance P immunoreactivity in dorsal root ganglia neurons innervating both uterus and colon in rats - Source: Journal of Neuroscience Research, online May 2008

  [ 26 votes ]   [ 1 Comment ]
By Victor Chaban, Li Jichang, et al. • • July 27, 2008

In women, clinical studies suggest that pain syndromes such as irritable bowel syndrome and interstitial cystitis [painful bladder], which are associated with visceral hyperalgesia [internal organs' increased pain sensitivity], are often comorbid with endometriosis and chronic pelvic pain.

One of the possible explanations for this phenomenon is viscerovisceral cross-sensitization, in which increased nociceptive [pain signaling] input from an inflamed pelvic organ sensitizes neurons that receive convergent input to the same dorsal root ganglion (DRG) from an unaffected visceral organ. [A DRG is a group of nerve cells located along a spinal nerve that monitors pain and relays information into the spinal cord so it can be analyzed by the brain.]

Nociception induces up-regulation of cellular mechanisms such as phosphorylated extracellular signal-regulated kinase (pERK) and substance P (SP), neurotransmitters associated with induced pain sensation.

The purpose of this study was to determine, in a rodent model, whether uterine inflammation increased the number of pERK- and SP-positive neurons that received input from both the uterus and the colon.

Cell bodies of colonic and uterine DRG were retrogradely labeled with fluorescent tracer dyes microinjected into the colon/rectum and into the uterus. Ganglia were harvested for fluorescent microscopy to identify positively stained neurons. Approximately 6% of neurons were colon specific and 10% uterus specific.

Among these uterus- or colon-specific neurons, up to 3-5% of DRG neurons in the lumbosacral neurons (L1-S3 levels) received input from both visceral organs.

Uterine inflammation increased the number of pERK- and SP-immunoreactive DRG neurons innervating specifically colon, or innervating specifically uterus, and those innervating both organs.

These results suggest that a localized inflammation activates primary visceral afferents, regardless of whether they innervate the affected organ [supply it with nerves]. This visceral sensory integration in the DRG may underlie the observed comorbidity of female pelvic pain syndromes.

Source: Journal of Neuroscience Research, online May 2008. PMID: 18478547, by Li J, Micevych P, McDonald J, Rapkin A, Chaban V. Department of Anesthesiology, Harbor UCLA Medical Center; Departments of Neurobiology and Obstetrics/Gynecology, David Geffen School of Medicine, University of California, Los Angeles; Department of Biomedical Sciences, Charles Drew University of Medicine and Science, Los Angeles, California, USA. [E-mail: Victor Chaban]

Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments Post a Comment

inflamation in the pelvis and colon aftwer hysterectomy
Posted by: englishrose24
Dec 2, 2008
i am still having pelvic pain even though i had a hysterectomy in 2000, i am also having pain in my rectom,and between the base of my spine. i am also have very pain full bladder, at times i end up doubled up on the floor.i have savere pain in my colon when i eat anything with cinnamin in it.the bladder pain ot worst after i fell face down from a hight of about 12 inches off a step,i have been that there is nothing to do damage to as i only have my bladder, left in my pelvis.i had a hysterectomy due to supposed to having endometreosise, but at hte time of my surgery they did not find any, they found that i had a intesternal site where it was connected together.please send me some information on what i should domto find out what i should do about my bladder pain. thanks liz T
Reply Reply
NAD+ Ignite with Niagen

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
SAD? Coping with Seasonal Affective Disorder SAD? Coping with Seasonal Affective Disorder
Safely Burn Away Body Fat Safely Burn Away Body Fat
How One Tiny Molecule Turned into One Huge Health Breakthrough How One Tiny Molecule Turned into One Huge Health Breakthrough
Natural Bladder Control, Go Less and Live More Natural Bladder Control, Go Less and Live More

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map