ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Study bodes well for low-carb eaters

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Omega Fix for Obesity: How the Right Fats Fight Fat

Potential of Quercetin in the Treatment of Melanoma

How Pomegranate May Protect Against Cancer

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Trimming the spare tire: Canola oil may cut belly fat

 
Print Page
Email Article

Amitriptyline in the treatment of fibromyalgia: A systematic review of its efficacy – Source: Rheumatology, Aug 12, 2008

  [ 78 votes ]   [ 2 Comments ]
By B Nishishinya, G Urrutia, et al. • www.ProHealth.com • August 16, 2008


[Note: Amitriptyline (brand name ElavilR) is a type of tricyclic antidepressant that has been tested in trials to determine its efficacy for improving sleep, pain and fatigue in non-depressed patients with Fibromyalgia - and has been prescribed off label for this purpose.]

The objective of this study was to assess the efficacy and safety of amitriptyline as a treatment of FM. A comprehensive computerized search in Medline (Pubmed), EMBASE and The Cochrane Library was performed. Randomized controlled trials (RCTs) comparing amitriptyline vs placebo in adult patients suffering from FM were identified, the methodological quality was assessed and the results of the main outcomes were evaluated.

Ten RCTs were identified. Large clinical variability and statistical heterogeneity precluded quantitative meta-analysis. Overall, the study quality was moderate to high.

  • Amitriptyline 25 mg/day (six RCTs) demonstrated a therapeutic response compared with placebo in the domains of pain, sleep, fatigue and overall patient and investigator impression.
  • This benefit was generally seen at 6-8 weeks of treatment but no effect was noted at 12 weeks.
  • Amitriptyline 50 mg/day (four RCTs) did not demonstrate a therapeutic effect compared with placebo.
  • Neither dose of amitriptyline had an effect on tender points count.
  • No clear statements on adverse events with amitriptyline can be made due to inconsistencies in data among the studies.

A definitive clinical recommendation regarding the efficacy of amitriptyline for FM symptoms cannot be made.

  • There is some evidence to support the short-term efficacy of amitriptyline 25 mg/day in FM.
  • There is no evidence to support the efficacy of amitriptyline at higher doses or for periods [more than] >8 weeks.

More stringent RCTs with longer follow-up periods are required to determine the long-term efficacy and safety of the amitriptyline and define its role in the multidisciplinary management of FM.

Source: Rheumatology (Oxford), Aug 12, 2008. [E-pub ahead of print] PMID: 18697829, by Nishishinya B, Urrútia G, Walitt B, Rodriguez A, Bonfill X, Alegre C, Darko G. Iberoamerican Cochrane Center, Universitat Autònoma de Barcelona, Spain; Kovacs Foundation, Palma de Mallorca; CIBER Epidemiología y Salud Pública, Spain; Washington Hospital Center, Washington DC, USA; Hospital de la Vall d'Hebron, Barcelona, Spain. [E-mail: gurrutia@santpau.es]





Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Optimized Curcumin Longvida® FibroSleep™


Article Comments Post a Comment

Elavil
Posted by: elbow
Aug 22, 2008
This is not a good drug to take if you have heart beat irregularities. I makes them much worse. Also one can gain a lot of weight on this drug. I take Trazodone at bedtime; half of a 25mg tablet. It deepens my sleep and I get a lot less pain now.
Reply Reply

Elavil
Posted by: tebeling-siravo
Sep 1, 2008
I agree. The Amitriptyline made my shaking worse and did not help with sleep. I also have been taking Trazadone for the last year and have found that it works for me. I take between 100-250 mg depending on my sleep and pain patterns. I started at 50 mg and the dosage was increased and regulated under medical supervision.
Reply Reply
 
Natural Pain Relief Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Thyroid Health and Fibromyalgia Thyroid Health and Fibromyalgia
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map