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76-Center Trial in 11 European Countries – To Study Experimental Blood Pressure Drug TAK-491 vs. Widely Prescribed Ramipril

  [ Not Yet Rated ]   [ Discuss This Article ] • September 26, 2008

This six-month study comparing the effectiveness and safety of the widely prescribed hypertension drug Ramipril vs Takeda Pharmaceutical’s investigational TAK-491 is recruiting at 76 centers in the Netherlands, Sweden, Bulgaria, Finland, Germany, Poland, Ukraine, Estonia, Russia, Slovakia, Serbia.

Study title: “ Efficacy and Safety Study of TAK-491 Compared to Ramipril for Treating Essential Hypertension,” ID # NCT00760214.

To quote from the detailed description at (

“Although antihypertensive agents are effective at the appropriate dose, the majority have side effects that limit their use. Angiotensin-converting enzyme inhibitors are commonly associated with cough and more rarely with angioedema. Beta-blockers are associated with fatigue and erectile dysfunction, calcium antagonists with peripheral edema and diuretics with metabolic complications.

“As a class, angiotensin II receptor blockers generally are considered more tolerable than other classes of hypertensive agents, although there is still a need for compounds with improved tolerability and efficacy for the treatment of hypertension. TAK-491 is an angiotensin II receptor blocker with high affinity for, and selective antagonistic activity at, the angiotensin II type 1 receptor, and is being developed for clinical use as an antihypertensive agent.”

“Ramipril is an angiotensin-converting enzyme inhibitor widely prescribed in Europe and Asia for the treatment of mild to moderate essential hypertension. This study is designed to compare the efficacy and safety/tolerability of TAK-491 and Ramipril for the treatment of hypertension.”

To Find More Information, Review Study Locations, and Contact the Study Managers: click here

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