ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Relief for IBS, Colitis, Crohn’s And More

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Restless Leg Syndrome (RLS) - are you running a marathon each night?

Can Magnesium Relieve Your Tinnitus?

Resveratrol Proven to Slow Brain Aging

Cassia Bark Oil: Why It's Valuable in Traditional Chinese Medicine

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Prenatal vitamin D could help prevent autism in children

Magnesium Protects Against Stroke, Heart Disease and Diabetes

 
Print Page
Email Article

International drug study shows rapid improvement in overactive bladder symptoms: Patients in 14-country study improved in as little as 3 days

  [ 1 vote ]   [ Discuss This Article ]
www.ProHealth.com • October 18, 2008


“On average patients taking solifenacin reported a 70 per cent reduction in severe urgency and urgency with incontinence.” - Professor Linda Cardozo

Patients with overactive bladders who took part in a multi-center study to measure the effectiveness of solifenacin noticed improvements in as little as three days, according to research published in the November issue of BJU International.(1) [Note: Solifenacin is an “antimuscarinic agent” - one that inhibits involuntary contraction of the detrusor muscle, which squeezes urine out of the bladder.]

Just over a hundred urology centers from 14 countries(2) took part in the study of 863 patients led by Professor Linda Cardozo from the Department of Urogynecology at King's College Hospital in London.

During the 16-week double-blind randomized study, neither the researchers nor the patients were aware of which were taking solifenacin and which were taking the placebo or dummy drug. Three times as many patients took the active drug as the placebo.

The aim of the study was to see what effect the drug had on overactive bladder problems, in which patients feel an urgent need to pass urine and some can become incontinent. A number of novel and subjective outcome measures were used to assess urgency.

"This is the first study to assess urgency as the primary endpoint using the Patient Perception of Intensity and Urgency Scale (PPIUS), which ranges from zero to four with grades three and four representing urgency and urgency incontinence" explains Professor Cardozo. "We also used the six-point Patients Perception of Bladder Condition score, visual analogue scales and patient diaries."

• Researchers found that on average patients taking solifenacin reported a 70 per cent reduction in severe urgency and urgency with incontinence, as measured by the PPIUS, compared with 50 per cent for those taking the placebo.

• There were also statistically significant improvements when it came to all levels of urgency, maximum urgency intensity and urgency bother.

The clinicians taking part in the study reported that they recorded significant improvements in the patients taking solifenacin when they attended their one-week clinic visit after starting to take the drug.

"Solifenacin was significantly more effective than the placebo as early as day three" says Professor Cardozo. "Patients reported that they passed urine less frequently and also reported significant reductions in the number of daily incontinence and urgency incontinence episodes.

"Less than 4 per cent of the patients reported mild or moderately severe side effects when they took 5mg or 10mg doses of the drug and just 3.6 per cent of the solifenacin group stopped taking the drug. Looking at the solifenacin study group as a whole, just under 16 per cent reported dry mouth problems and 7 per cent reported constipation.

"Just over 2 per cent of patients on the placebo also reported side effects. Three per cent reported dry mouth problems and two per cent reported constipation. It is common to notice a quite strong placebo effect in overactive bladder trials and this study is no exception. However, even a relatively small difference between active treatment and placebo outcomes might have a large influence on quality of life and treatment success."

The study was carried out in two eight-week segments. In the first eight weeks 640 patients (74 per cent) were given 5mg daily of solifenacin and the remaining 223 received the placebo. At the end of eight weeks, 46.5 per cent of patients receiving solifenacin requested a dose increase, as did 66 per cent of the patients receiving the placebo.

Half of the solifenacin patients had their dose doubled from 5mg to 10mg and the other half were left on 5mg. The results from this secondary analysis will be published at a later date.

Approximately nine out of ten study participants were female and their average age was 58. Most had suffered from an overactive bladder for three to four years. Patients were selected if they had suffered from an overactive bladder for more than three months and had had three or more urgency episodes, with or without incontinence, in the last three days. They had to be willing and able to keep a diary on when they emptied their bladder and the level of urgency and degree of bother they experienced.

"The rapid improvement that patients taking solifenacin reported is very important as patient expectations are high when they experience this highly distressing condition and they can become easily disillusioned if they don't see early results" says Professor Cardozo, who wrote the international paper with experts from Germany, Italy, Spain, Belgium and The Netherlands.

"Our study found that solifenacin was consistently effective at reducing urgency and other symptoms associated with an overactive bladder and that simple scoring scales, such as the PPIUS, are a reliable way of measuring treatment outcome."

* * * *

1. See “Solifenacin in the treatment of urgency and other symptoms of overactive bladder: Results from a randomized, double-blind, placebo-controlled, rising-dose trial,” Cardozo L, et al. BJU International, Nov 2008.

2. The SUNRISE study - the name is an acronym of the full study title – was conducted at centers in Belgium, Czech Republic, Egypt, France, Germany, Greece, Hungary, Italy, Poland, Portugal, Russia, Slovakia, Spain and the UK.
____
Source: Wiley-Blackwell publisher press release, Oct 9, 2008.

Note: This information has not been evaluated by the FDA. It is generic and is not meant to prevent, diagnose, treat or cure any illness, condition, or disease. It is very important that you make no change in your healthcare plan or health support regimen without researching and discussing it in collaboration with your professional healthcare team.




Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Mitochondria Ignite™ with NT Factor® Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

The Super Antioxidant for Brain, Joint and Heart Health The Super Antioxidant for Brain, Joint and Heart Health
Clinically Studied Joint Relief Product for FM & ME/CFS Clinically Studied Joint Relief Product for FM & ME/CFS
Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map