Purpose of review: Quercetin is discussed since several decades as a multipotent bioflavonoid with great potential for the prevention and treatment of disease. [Quercetin is a plant-based chemical compound which acts as a pigment and is derived from such colored foods as green tea, berries, grapes, broccoli.]
In the current review, we present the most recent findings on quercetin with regard to:
• The pharmacology,
• The in-vitro and in-vivo effects in different cell systems and animal models,
• And the clinical effects in humans.
• Quercetin bioavailability has been underestimated in the past and can be improved by food matrix components or particular delivery forms.
• Among the biological effects of particular relevance, the antihypertensive effects of quercetin in humans and the improvement of endothelial function should be emphasized.
• Together with its antithrombotic and anti-inflammatory effects, the latter mainly mediated through the inhibition of cytokines and nitric oxide, quercetin is a candidate for preventing obesity-related diseases.
• Most exciting are the findings that quercetin enhances physical power by yet unclear mechanisms.
• The anti-infectious and immunomodulatory activities of quercetin might be related to this effect.
Summary: Quercetin is a most promising compound for disease prevention and therapy; however, many of the effects still need confirmation by human intervention trials.
Source: Current Opinion in Clinical Nutrition & Metabolic Care, Nov 2008.11(6):733-740, PMID, Bischoff, Stephan C. Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany. [E-mail: firstname.lastname@example.org]