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Quercetin: Potentials in the prevention and therapy of disease – Source: Current Opinion in Clinical Nutrition & Metabolic Care, Nov 2008

  [ 28 votes ]   [ Discuss This Article ]
By Stephan C Bischoff • www.ProHealth.com • October 29, 2008


Purpose of review: Quercetin is discussed since several decades as a multipotent bioflavonoid with great potential for the prevention and treatment of disease. [Quercetin is a plant-based chemical compound which acts as a pigment and is derived from such colored foods as green tea, berries, grapes, broccoli.]

In the current review, we present the most recent findings on quercetin with regard to:

• The pharmacology,

• The in-vitro and in-vivo effects in different cell systems and animal models,

• And the clinical effects in humans.

Recent findings:

• Quercetin bioavailability has been underestimated in the past and can be improved by food matrix components or particular delivery forms.

• Among the biological effects of particular relevance, the antihypertensive effects of quercetin in humans and the improvement of endothelial function should be emphasized.

• Together with its antithrombotic and anti-inflammatory effects, the latter mainly mediated through the inhibition of cytokines and nitric oxide, quercetin is a candidate for preventing obesity-related diseases.

• Most exciting are the findings that quercetin enhances physical power by yet unclear mechanisms.

• The anti-infectious and immunomodulatory activities of quercetin might be related to this effect.

Summary: Quercetin is a most promising compound for disease prevention and therapy; however, many of the effects still need confirmation by human intervention trials.

Source: Current Opinion in Clinical Nutrition & Metabolic Care, Nov 2008.11(6):733-740, PMID, Bischoff, Stephan C. Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany. [E-mail: bischoff.stephan@uni-hohenheim.de]





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