ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Coconut Oil Healthy? (The American Heart Association Doesn’t Think So)

American Heart Association Renders Itself Obsolete With 1960s Dietary Advice on Coconut Oil

Ginger Fights Obesity

Health Benefits of Artichokes

Putting the Spotlight on Coriander Seed Oil

Migraines? Powdered Ginger May Help

Are Americans Really Getting Too Much Vitamin D? A Critical Look at Recent Media Warnings

Eating more vegetable protein may protect against early menopause

Vitamin C and antibiotics: A new one-two 'punch' for knocking-out cancer stem cells

German Chamomile Oil: A Versatile Essential Oil You Should Have at Home

 
Print Page
Email Article

Use of proton pump inhibitors [stomach acid reducing drugs] and risk of osteoporosis-related fractures – Source: Canadian Medical Association Journal – Aug 2008

  [ 34 votes ]   [ Discuss This Article ]
By Laura E Targownik, MD, William D. Leslie, MD, et al. • www.ProHealth.com • October 30, 2008


[Note: To read the full text of this article free, click here. Proton pump inhibitors - designed to inhibit stomach acid production - are among the most-prescribed drugs in the world. On the other hand, hypochlorhydria – insufficient stomach acid - prevents protein digestion and absorption of nutrients including the calcium and vitamin B12 needed to avoid leaching of calcium from bones and to replace old bone with new.]

Background: The use of proton pump inhibitors has been associated with an increased risk of hip fracture. We sought to further explore the relation between:

• Duration of exposure to proton pump inhibitors

• And osteoporosis-related fractures.

Methods: We used administrative claims data to identify patients with a fracture of the hip, vertebra, or wrist between April 1996 and March 2004. Cases were each matched with 3 controls based on age, sex and comorbidities. We calculated adjusted odds ratios (OR) for the risk of hip fracture and all osteoporosis-related fractures for durations of proton pump inhibitor exposure ranging from 1 or more years to more than 7 years.

Results: We matched 15,792 cases of osteoporosis-related fractures with 47,289 controls.

• We did not detect a significant association between the overall risk of an osteoporotic fracture and the use of proton pump inhibitors for durations of 6 years or less.

• However, exposure of 7 or more years was associated with increased risk of an osteoporosis-related fracture (adjusted OR 1.92, 95% confidence interval [CI] 1.16-3.18, p = 0.011). [Note: an odds ratio of 1.0 would mean there is no difference in risk. An OR of 1.92 means the risk of an osteoporosis-related vertebra, wrist, or other fracture is 92% greater among the group taking proton pump inhibitors.]

• We also found an increased risk of hip fracture after 5 or more years of exposure (adjusted OR 1.62, 95% CI 1.02-2.58, p = 0.04) [62% greater risk of hip fracture].

• With even higher risk after 7 or more years exposure (adjusted OR 4.55, 95% CI 1.68-12.29, p = 0.002) [355% greater risk of hip fracture].

Interpretation:

• Use of proton pump inhibitors for 7 or more years is associated with a significantly increased risk of an osteoporosis-related fracture.

• There is an increased risk of hip fracture after 5 or more years exposure.

Further study is required to determine the clinical importance of this finding and to determine the value of osteoprotective medications for patients with long-term use of proton pump inhibitors.

Source: Canadian Medical Association Journal – Aug 2008, 12;179(4):306-7. PMID: 18695179, by Targownik LE, Lix LM, Metge CJ, Prior HJ, Leung S, Leslie WD. Department of Gastroenterology, Division of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. [E-mail: bleslie@sbgh.mb.ca]





Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Enhance Eyelashes Naturally Enhance Eyelashes Naturally
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health
Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map