Background: Fish and seafood omega-3 fatty acids may prevent or delay the progression of prostate cancer, but epidemiologic studies do not uniformly support this hypothesis.
Objective: We examined the relation of fish and seafood omega-3 fatty acid intakes with prostate cancer incidence and mortality.
Design: We conducted a prospective cohort study among 20,167 men participating in the Physician's Health Study who were free of cancer in 1983.
• During 382,144 person-years of follow-up, 2,161 men were diagnosed with prostate cancer and 230 died of prostate cancer.
• Fish intake was unrelated to prostate cancer incidence.
• Survival analysis among the men diagnosed with prostate cancer revealed that those consuming fish 5 or more times a week had a 48% lower risk of prostate cancer death than did men consuming fish less than once weekly [relative risk (RR) = 0.52; 95% CI: 0.30, 0.91; P for trend = 0.05].
• A similar association was found between seafood omega–3 fatty acid intake and prostate cancer mortality (RRQ5 versus Q1= 0.64; 95% CI: 0.42, 0.99; P for trend = 0.02). These associations became stronger when the analyses were restricted to clinically detected cases.
Conclusion: These results suggest that fish intake is unrelated to prostate cancer incidence but may improve prostate cancer survival.
Source: American Journal of Clinical Nutrition, Nov 2008, 88(5), 1297-1303. Chavarro JE, Stampfer MJ, Hall MN, Sesso HD, Ma J. Departments of Nutrition (JEC and MJS) and Epidemiology, Harvard School of Public Health; Channing Laboratory and Divisions of Aging and Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA. [E-mail: