ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?

All About Ginkgo Biloba: Benefits of This Timeless Herbal Supplement

Yarrow Oil: Here's Why It Deserves a Place in Your First-Aid Kit

Artificial sweeteners linked to risk of weight gain, heart disease and other health issues

Trial Finds Reduction in Depressive Symptoms Following Magnesium Supplementation

Vitamin D supplement use associated with lower risk of breast cancer

Carnitine deficiency suggested as contributor to autism

Hop Oil: A Safe Sleep Aide

White Camphor Oil: The Purest Camphor Oil

Lutein — An Important Nutrient for Eye and Brain Health

 
Print Page
Email Article

Bad LDL cholesterol interferes with breakdown of stored fat

  [ 1 vote ]   [ Discuss This Article ]
By Karolinska Institutet, Sweden • www.ProHealth.com • November 30, 2008


The so called bad cholesterol (LDL) inhibits the breakdown of fat in cells of peripheral deposits, according to a study from the Swedish medical university Karolinska Institutet. [ LDL cholesterol is known to be raised by trans fats (hydrogenated oils) in the diet. “Peripheral” fat deposits are those in the arms, legs, head, and buttocks.]

The discovery reveals a novel function of LDL as a regulator of fat turnover besides its well-established detrimental effects in promoting atherosclerosis [plaque buildup on inside of arteries]. The study, which is a collaboration of two research groups at Karolinska Institutet, is published in the open-access journal PLoS ONE.* It shows that LDL cholesterol slows the rate of fat breakdown (i.e., lipolysis) in adipocytes, the peripheral cells responsible for fat storage. Previously, it has been known that release of free fatty acid from the peripheral fat to the blood stream increases the synthesis of LDL precursors in the liver.

"The results of our study provide evidence of a reciprocal link between the liver and peripheral fat regulating fat turnover," says study-initiator Dr. Johan Bjorkegren. The discovery also opens up for new theories for the well-established association between blood lipids and the metabolic syndrome. [A group of risk factors, including high blood pressure, obesity, high cholesterol, & insulin resistance, that if present increase risk of diabetes and cardiovascular disease.]

"If proven of general physiological importance, therapies lowering LDL, as for instance Statins, may also affect the turnover of peripheral fat," continues Dr Bjorkegren.

The study and has been performed on cell cultures and tissues from humans as well as mouse models with different levels of LDL. The inhibitory effect was also shown to be dependent on LDL receptors on the surface of the fat cells.

"The exact intracellular mechanism for how the binding of LDL to the surface of the fat cells inhibits the breakdown of intracellular fat remains to be revealed," says project leader Dr. Josefin Skogsberg.

* The full text of this publication is available free at PubMedCentral. See: “ApoB100-LDL Acts as a Metabolic Signal from Liver to Peripheral Fat Causing Inhibition of Lipolysis in Adipocytes," PLoS ONE, Nov 20, 2008, by Johan Björkegren [E-mail: johan.bjorkegren@ki.se], Josefin Skogsberg [E-mail: josefin.skogsberg@ki.se], et al.




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Energy NADH™ 12.5mg Optimized Curcumin Longvida®


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Breaking Through the Mental Fog Breaking Through the Mental Fog
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic
How Glutathione Can Save Your Life How Glutathione Can Save Your Life
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
Vital Molecule Increases Cellular Energy and Improves Cognitive Function Vital Molecule Increases Cellular Energy and Improves Cognitive Function

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map