ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimm...

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Acupressure reduced fatigue in breast cancer survivors

Omega-3 fatty acid stops known trigger of lupus

What’s Fenugreek Good For?

Print Page
Email Article

Bad LDL cholesterol interferes with breakdown of stored fat

  [ 1 vote ]   [ Discuss This Article ]
By Karolinska Institutet, Sweden • • November 30, 2008

The so called bad cholesterol (LDL) inhibits the breakdown of fat in cells of peripheral deposits, according to a study from the Swedish medical university Karolinska Institutet. [ LDL cholesterol is known to be raised by trans fats (hydrogenated oils) in the diet. “Peripheral” fat deposits are those in the arms, legs, head, and buttocks.]

The discovery reveals a novel function of LDL as a regulator of fat turnover besides its well-established detrimental effects in promoting atherosclerosis [plaque buildup on inside of arteries]. The study, which is a collaboration of two research groups at Karolinska Institutet, is published in the open-access journal PLoS ONE.* It shows that LDL cholesterol slows the rate of fat breakdown (i.e., lipolysis) in adipocytes, the peripheral cells responsible for fat storage. Previously, it has been known that release of free fatty acid from the peripheral fat to the blood stream increases the synthesis of LDL precursors in the liver.

"The results of our study provide evidence of a reciprocal link between the liver and peripheral fat regulating fat turnover," says study-initiator Dr. Johan Bjorkegren. The discovery also opens up for new theories for the well-established association between blood lipids and the metabolic syndrome. [A group of risk factors, including high blood pressure, obesity, high cholesterol, & insulin resistance, that if present increase risk of diabetes and cardiovascular disease.]

"If proven of general physiological importance, therapies lowering LDL, as for instance Statins, may also affect the turnover of peripheral fat," continues Dr Bjorkegren.

The study and has been performed on cell cultures and tissues from humans as well as mouse models with different levels of LDL. The inhibitory effect was also shown to be dependent on LDL receptors on the surface of the fat cells.

"The exact intracellular mechanism for how the binding of LDL to the surface of the fat cells inhibits the breakdown of intracellular fat remains to be revealed," says project leader Dr. Josefin Skogsberg.

* The full text of this publication is available free at PubMedCentral. See: “ApoB100-LDL Acts as a Metabolic Signal from Liver to Peripheral Fat Causing Inhibition of Lipolysis in Adipocytes," PLoS ONE, Nov 20, 2008, by Johan Björkegren [E-mail:], Josefin Skogsberg [E-mail:], et al.

Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® FibroSleep™ Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
Health Benefits Are Brewing in Green Tea Health Benefits Are Brewing in Green Tea

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map