Gamma-aminobutyric acid [GABA] is a major inhibitory neurotransmitter in the central nervous system. [It is responsible for controlling the delicate balance between physiological acceleration and “braking” (inhibition), as needed.]
GABA metabolism is dependent on the activity of three enzymes: glutamic acid decarboxylase, GABA-transaminase and succinic semialdehyde dehydrogenase.
Decreased activity of these enzymes may cause many neurological syndromes, such as stiff-person syndrome, chronic fatigue syndrome, anxiety disorders and seizures.
This article is a review of most important problems related to an impairment of GABA metabolism.
Source: Postepy Biochemii, 2007;53(4):356-60. PMID: 19024900, by Kowalski A, Rebas E, Zlinska L. Department of Molecular Neurochemistry, Medical University of Lodz, Lodz, Poland. [E-mail: firstname.lastname@example.org]