Background: Psychological distress (PD) and depressive symptoms are commonly observed during menopausal transition. Studies suggest that omega-3 (n-3) fatty acids may help alleviate depression.
Objective: The objective was to compare enriched ethyl-eicosapentaenoic acid (E-EPA) supplementation with placebo for the treatment of PD and depressive symptoms in middle-aged women.
Design: Women with moderate-to-severe PD (n = 120) were randomly assigned to receive 1.05 g E-EPA/d plus 0.15 g ethyl-docosahexaenoic acid/d (n = 59) or placebo (n = 61) for 8 wk.
The main outcomes were 8-wk changes in psychological distress scores [Psychological General Well-Being Schedule (PGWB)] and depressive scales [20-item Hopkins Symptom Checklist Depression Scale (HSCL-D-20) and the 21-item Hamilton Depression Rating Scale (HAM-D-21)].
At baseline, women with PD were mildly to moderately depressed, and 24% met the major depressive episode (MDE) criteria of the Diagnostic and Statistical Manual of Mental Disorders, 4th edition.
After 8 weeks, outcomes improved in both groups, but no significant differences were noted between them.
Stratification analyses for MDE diagnosis at baseline indicated that differences in adjusted 8-wk changes between the E-EPA group without major depressive episode (n = 46) and the placebo group (n = 45) were 8.0 (95% CI: 0.6, 15.3; P = 0.034) for the PGWB, -0.2 (95% CI: -0.01, -0.4; P = 0.040) for the HSCL-D-20, and -2.7 (95% CI: -0.3, -5.1; P = 0.030) for the HAM-D-21.
Differences in adjusted 8-wk changes between the E-EPA group with major depressive episode (n = 13) and the placebo group (n = 16) were not significant.
Conclusion: To our knowledge, this is the first trial of n-3 supplementation in the treatment of psychological distress and depressive symptoms in middle-aged women.
In women with psychological distress without major depressive episode at baseline, the 8-wk changes in PD and depressive scales improved significantly more with E-EPA than with placebo.
This trial was registered at http://www.controlled-trials.com as ISRCTN69617477.
Source: American Journal of Clinical Nutrition, Dec 30, 2008. Lucas M, Asselin G, Mérette C, Poulin MJ, Dodin S. PMID: 19116322, by Laval University, Saint-François d'Assise Hospital, Quebec, Canada.