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Dietary Reference Intakes for vitamin D: Justification for a review of the 1997 values - Source: American Journal of Clinical Nutrition, March 2009

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By Elizabeth A Yetley, et al. (U.S. & Canadian Govt Working Group) • • February 20, 2009

Recent Institute of Medicine (IOM) reviews of the process for deriving Dietary Reference Intakes (DRIs) suggest that determining the need for a new nutrient review should be evaluated against criteria set a priori. After selecting the criterion of significant new and relevant research, a working group of US and Canadian government scientists used results from a systematic review and 2 conferences on vitamin D and health to evaluate whether significant new and relevant scientific evidence had become available since the 1997 IOM publication of the DRIs for vitamin D.

This working group concluded that there appears to be new research meeting the criteria for 4 key DRI questions. The new research is of larger quantity and quality for the elderly than for other groups, but overall:

1. Adds to the bone-related and status evidence available to the 1997 DRI Committee for several of the life-stage groups,

2. Identifies new outcomes with respect to risk of falls and performance measures in the elderly and potential adverse effects,

3. Provides additional information on dose-response relations between intakes and circulating 25-hydroxyvitamin D concentrations and between 25-hydroxyvitamin D concentrations and several health outcomes (i.e., bone-related outcomes for all ages and risk of falls and performance measures in older adults).

Members of the working group concluded that significant new and relevant research was available for reviewing the existing DRIs for vitamin D while leaving the decision of whether the new research will result in changes to the current DRIs to a future IOM-convened DRI committee.

Source: American Journal of Clinical Nutrition, March 2009, 89(3)719-727. Yetley EA, Brule D, Cheney MC, Davis CD, Esslinger KA, Fischer P, Friedl KE, Greene-Finestone LS, Guenther PM, Klurfeld DM, L’Abbe MR, McMurry KY, Starke-Reed PE, Trumbo PR. Agricultural Research Service and Center for Nutrition Policy and Promotion, US Department of Agriculture, Washington, DC; US Army Medical Research and Material Command, Ft Detrick, MD; Bureau of Nutritional Sciences, Food Directorate, and Office of Nutrition Policy and Promotion, Health Canada, Ottawa, Canada; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD; Division of Nutrition Research Coordination, National Cancer Institute, and Office of Dietary Supplements, National Institutes of Health, Bethesda, MD; Office of Disease Prevention and Health Promotion, US Department of Health and Human Services, Washington, DC; Public Health Agency of Canada, Ottawa, Canada. [E-mail:]

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