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Suppressing Cancer with a Master Control Gene

  [ 5 votes ]   [ Discuss This Article ] • February 23, 2009

“There is a good chance that the gene can be switched on again with a drug.”

Starting with the tiny fruit fly and then moving into mice and humans, [Belgian researchers] show that expression of the same gene suppresses cancer in all three organisms. Reciprocally, switching off the gene – called Ato in flies and ATOH1 in mammals – leads to cancer.

The authors show there is a good chance that the gene can be switched on again with a drug. They report their findings in two papers in the leading online open access journal PLoS Biology.*

All of us begin our lives as a single cell (made when an egg and sperm fuse) which repeatedly divides into the few billion cells that constitute an adult human. During these divisions cells become increasingly differentiated from each other, until in an adult almost all cells are highly specialized to perform a specific function – skin cells, liver cells, eye lens cells, nerve cells, etc.

Cancer is a collection of cells without a function, which grow when normal genetic controls of cell division are interrupted. Cancer cells are less differentiated than normal cells – leading to the hypothesis that the final steps of differentiation prevent cells from becoming cancerous.

New work conducted by Wouter Bossuyt, Bassem Hassan, and colleagues [at the Department of Molecular and Developmental Genetics, VIB and KU Leuven School of Medicine, Leuven, Belgium] has tested this theory. They demonstrate that in the fruit fly, master control genes steering the specialization step inhibit tumor formation.

In collaboration with colleagues from the United States, they show that loss of one of those genes, Atonal homolog 1 (ATOH1), causes colon cancer in mice. The gene regulates the last step in the specialization to epithelial cells of the colon. Humans with colon cancer frequently have an inactivated ATOH1 gene, the researchers show.

The researchers [were able to] reactivate the gene in human colon cancer cells grown in culture. This caused the tumor cells to stop growing and commit suicide.

This exciting, but preliminary, result suggests that it may be possible to switch the gene back on in living patients to target their cancers. Taking this work in the test tube and using it to develop a therapy is an exciting but complicated challenge. Therefore, more work will be required to further understand the role of ATOH1 in suppressing cancer formation.

Source: Public Library of Science news release, Feb 23, 2009

* See Free Access Articles: “Atonal homolog 1 is a tumor suppressor gene” and “The Atonal proneural transcription factor links differentiation and tumor formation in Drosophila”

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